A Country-Wide Study of Genotyping and Drug Resistance Characteristics of Mycobacterium tuberculosis Isolates from Kyrgyz Republic
Project Status: 3 Approved without Funding
Duration in months: 36 months
Objective
Kyrgyzstan, a highland Central Asian country of the former Soviet Union is marked by a high TB incidence of 141/100,000 civilian population (WHO, 2012). In Kyrgyzstan’s prisons, the rates of infection are around 40 times higher than in the general population, and case fatality rates are some 60 times higher (International Committee of the Red Cross, 2009).
TB treatment effectiveness depends on quick detection of the pathogen, its identification and the drug susceptibility testing. Culture examination is laborious, time-consuming (2-3 months) and prevents rapid choice of an alternative treatment scheme.
The prevalence of tuberculosis in humans and animals in Kyrgyzstan is one of the highest worldwide. Currently, there is very limited understanding of tuberculosis transmission in-between livestock and humans. It is important to understand the epidemiology and the main transmission routes in order to establish a disease control strategy. Tuberculosis can ultimately only be eliminated if the disease is controlled in the reservoir and human and animal health is inextricably intertwined. It is therefore necessary to consider human and animal health strategies as two aspects of the same aim. The goal of the current study is to describe the distribution and the transmission dynamics of tuberculosis in Kyrgyzstan and to determine the levels of antibiotic resistances and its impact on finances and public as well as to compare isolates with the global phylogeny of members of the Mycobacterium tuberculosis complex. The results of the study should contribute to develop an efficient tuberculosis control strategy in Kyrgyzstan.
Participating Institutions
LEADING
National Center of Cardiology and Internal Medicine / Institute of Molecular Biology and Medicine
PARTICIPATING
National Center of Phthisiology
COLLABORATOR
National Reference Center (NRC) for Mycobacteria and antituberculous drug resistance
