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Correction of Stress-Inducted Immunodeficiencies

#3417


Production of substances featuring high anti-infectious and antitumor activity to be used for scientifically grounded correction of stress-induced immunodeficiency of persons being under extreme conditions

Tech Area / Field

  • MED-DRG/Drug Discovery/Medicine
  • MED-OTH/Other/Medicine
  • BIO-MIB/Microbiology/Biotechnology
  • BIO-SFS/Biosafety and BioSecurity/Biotechnology

Status
3 Approved without Funding

Registration date
06.12.2005

Leading Institute
JSC Biochimmash, Russia, Moscow

Supporting institutes

  • Gamalei Institute of Epidemiology and Microbiology, Russia, Moscow

Collaborators

  • Mercer University / School of Medicine, USA, GA, Macon\nMicrogen Laboratories, USA, TX, La Marque

Project summary

Nowadays extreme conditions and adverse ecological factors lead to decrease in herd immunity of the population resulting in growth of incidence of infectious and noninfectious diseases, emergence of stress-dependent illnesses, chronicalization of diseases, genetical abnormalities, high death rate. Even 20 years ago the percentage of healthy population comprised 30% while now it is no more than 15%. It should be noted that in spite of the progress in medical science the available methods and medications for treatment of virus, bacterial and other diseases do not exhibit proper effectiveness. At the same time it is well-known that modified agents of extremely dangerous, uncontrollable or slow infections as well as oncogenes and oncogenic viruses can be used for biological aggression. In this connection the search for new approaches to the cure for stress-induced diseases and the development of medicinal preparations for protection in case of biological warfare is obviously an urgent problem.

So, the present-day challenge is to produce new highly effective prophylactic and therapeutic agents to deal with the most dangerous and widespread diseases of viral, bacterial and noninfectious origin. The research and development activities in the field of new anti-infective, anticancer and immunomodulatory medicinal preparations being proposed is considered to contribute to solution of the problem. We plan to do the work aimed at production of the preparations for treatment as well as prevention of virus, bacterial and oncological diseases with reference to various population groups being under extreme conditions (e.g. spacemen, submariners, etc.)

Investigation of the specific activity of substances of different origin using cell cultures makes it possible to give a preliminary estimate of their effectiveness with the extrapolation on entire organism of human and animals. As a result of many years' work we have gained a wealth of experience related to in vitro and in vivo investigation of the preparation activity so that we are able to predict the effectiveness of prospective preparations with a high degree of certainty. In vitro determination of antiviral, toxic and antineoplastic action of the preparations takes no longer than from 3 to 7 days using blood cells and normal cell cultures of human (fibroblasts of lungs of human embryo) and animals (L-929 fibroblasts of mouse) as well as human neoplastic cell cultures including: MG-63 (human osteosarcoma), CaOV (ovarian carcinoma), HeLa (carcinoma of uterine cervix), J-96 (mononuclear leucosis), MT-4 (MOLT) (T-cell leukemia), Daudi (B-cell leukemia), K-562 (myeloma), etc. The findings resulted from the research on human neoplastic cells can be evidence of antitumor activity of the investigated preparations in certain concentration range.

It is planned to carry out in vitro experimental investigation of a broad spectrum of cytokines (such as IFN-α, IFN-γ, TNF-α IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-18, etc.) produced by human neoplastic cells under the action of the substances selected as potential medicinal preparations and various combinations of those. This study is necessary to model the action of the investigated substances on human immune system in case of stress-induced diseases.


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