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Biologically Active Metal Complexes

#G-609


New Production Technologies of Raw Materials and Syntheses of Biologically Active Metal-Complexes on Their Base

Tech Area / Field

  • BIO-CHM/Biochemistry/Biotechnology
  • MAT-OTH/Other/Materials

Status
3 Approved without Funding

Registration date
16.10.2000

Leading Institute
Institute of Metallurgy, Georgia, Tbilisi

Supporting institutes

  • Georgian Technical University, Georgia, Tbilisi

Project summary

We propose to exploit an energy-saving, environmentally safe “green” technology affording production of pure metals to provide metals used in medicine as essential nutrients. We propose to explore methods to convert the metals in coordination compounds, rendering the pure metals from our demonstrated low oxygen pressure process as bioviable precursors. Applications include medicines for both humans and animals, nutrients for humans, animals and plants, and also for microorganisms used in toxic waste management. This technology and the associated staff will thus be redirected towards peaceful long term applications of our green technology. Microelements being present in albumines, ferments and hormones play an active role in all biological processes in the organism. Therefore, regulation of infringed metabolism, following different diseases, is of huge significance. Purposeful syntheses of coordinate compounds of bioactive ligands with “metals of life” and establishment of general regularities of triad “synthesis-structure-property” can successfully solve the most complicated problems of living matter. The purpose of the project is focused on development of the new economical, environmentally friendly production processes of pure bio-metals (Cu, Zn, V, Mn, Fe, Co, Ni, Mo) and some of the lowest oxides for direct synthesis of their coordinate compounds with bioligands. Pure metals and some their lowest oxides will be obtained by thermal dissociation of corresponding higher oxides ingaseous environment with ultra-low partial pressure of oxygen. The necessary gas atmosphere may be created in a closed system by removal of oxygen from its working volume, that according to our method allows to carry out, during some seconds, superdeep cleansing of high-temperature reactor atmosphere from oxygen up to 10-28 atm. Thermal dissociation practically of any oxide is possible under these conditions.

Conversion of weapon-industrial complexes put forward a problem of utilization of ferrous, non-ferrous and rare metals as well as of their oxides and salts. Most of them can be used after their recycling as raw materials for synthesis of biologically active metal complexes. It is intended to conduct a direct syntheses of coordinate compounds in liquid phase by interaction of the reduced metals, and in some cases of their lowest oxides, with non-aqueous solutions of hydrazides of different carbonic acids. Guanidine, aminoguanidine and histidine will be used as bioligands as well. Halide, sulphate, nitrate and thiocyanate will be applied as acidoligands. The same ligands will be used to carry out ordinary syntheses in order to establish correlations among composition, molecular structure and biological activity of metal-complexes as well as for comparison with outcomes resulting from the new method of direct syntheses. We plan to fulfil the quantum-chemical calculations that allow to predict donor abilities of initial substaces appearing in the role of ligands. This prediction will economize expenditure on reagents, duration of syntheses, and what is of great significance, it will give the predicted character to the synthesis. The produced metal-complexes will be tested in vitro and in vivo, and the most prospective ones will be delivered for clinical tests in order to create new medical product.


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