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Low Field Effects on Cellular Membrane

#A-890


The Study of the Membrane Target for Extremely Low-frequency Electromagnetic Field (ELF EMF)

Tech Area / Field

  • BIO-CHM/Biochemistry/Biotechnology
  • BIO-CGM/Cytology, Genetics and Molecular Biology/Biotechnology

Status
3 Approved without Funding

Registration date
20.05.2002

Leading Institute
UNESCO Chair in Life Sciences - Life Sciences International Educational Center, Armenia, Yerevan

Supporting institutes

  • Tbilisi State Medical University, Georgia, Tbilisi\nL.A.Orbeli Institute of Physiology, Armenia, Yerevan\nBelarusian Medical Academy for Postgraduate Education, Belarus, Minsk\nYerevan State Medical University, Armenia, Yerevan\nInstitute of Radiophysics and Electronics, Armenia, Ashtarak-2

Collaborators

  • Universidade de Lisboa, Portugal, Lisbon\nUniversity of Colorado, USA, CO, Boulder\nCEO AMRI PA, USA, PA, Hanover\nEMF Therapeutics, Inc., USA, TN, Chattanooga

Project summary

At present the biological effect of ELF EMF can be considered as a proven fact. It is known that ELF EMF-induced metabotropic effects on biological systems realized through the water structure changing are frequency-dependent. The most effective ELF EMF modulation of the physicochemical properties of cell bathing solution and the cell functional activity occurs at less than 20 Hz frequencies. Previously it was established that cyclic nucleotides-dependent Na:Ca exchange plays a crucial role in metabolic pathways responsible for the ELF EMF biological effects. On the basis of these data it is suggested that cyclic nucleotides-dependent Na:Ca exchanger serves as membrane sensor for ELF EMF. The aim of the project is to check this hypothesis by studying the role of Na:Ca exchange in the ELF EMF-induced effect on the number of Ca-dependent functional activity of different cells. For this purpose the effect of ELF EMF in following experimental models will be investigated:

– cellular membrane enzyme activity and NO production;


– Na-K pump and Na:Ca exchange activity;
– intracellular messenger systems;
– membrane chemosensitivity;
– membrane excitability;
– the releasing process of parathyroid hormone (PTH);
– synaptic plasticity in CNS of mammals;
– the afferent activity in skin branches of somatic nerves;
– behavioral activity of rats.

The results of the investigation will clarify the cellular and molecular mechanisms of ELF EMF biological effect on cells, guiding the users of ELF EMF for therapeutic purpose. The data will also be applicable for evaluation and worldwide harmonization of EMF safety standards.


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