Prophylaxis and Treatment of Myocardial Infarction
Myocardial Infarction: New Approaches to Prophylaxis and Treatment; Apoptosis Regulation
Tech Area / Field
- MED-DRG/Drug Discovery/Medicine
8 Project completed
Senior Project Manager
Institute of Theoretical and Experimental Biophysics, Russia, Moscow reg., Puschino
- Institute of Immunological Engineering, Russia, Moscow reg., Lyubuchany
- University of Helsinki / Department of Applied Chemistry and Microbiology, Finland, Helsinki\nUniversite Claude Bernard - Lyon I, France, Lyon
Project summaryThe aim of the Project: to construct cardioprotectors of a new generation based on their ability to activate the mitochondrial ATP-dependent K+ (mitoKATP) channel and to study the mechanisms of apoptosis and necrosis development in cardiac pathologies.
Cardiovascular disorders, in spite of the efforts aimed at their prevention, are the main cause of mortality in the population. Therefore it is important to develop principally new approaches for prevention and treatment based on the latest achievements of basic sciences. One such approach is the search for activators of ATP-dependent K+ channels, playing nowadays an important part in prevention of myocardial infarctions in ischemia.
The Project participants first detected and isolated from tissues a mitochondrial ATP-dependent K+ channel and at present are studying the structure and function of this channel. Lately, this channel became intensely studied in many laboratories of the world, as it was shown that its activation with pharmacological agents prevented development of experimental myocardial infarctions. In this approach we begun a search for metabolic channel activators, assuming that such agents possessing cardioprotector properties could be less toxic for the organism. In addition; a metabolic regulation at the level of natural modulators is possible inside the cell. The basic part of the Project is devoted to the testing of the cardioprotector properties of natural activators of the mitoKATP channel in order to construct a new generation of preparations protecting the heart from ischemia induced damage. The Projects involve the continuation of the study of the channel structure and identification of possible mechanisms of apoptosis and necrosis recovered in myocardial ischemia.