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Materials for Implant Medicine

#1530


Porous Mineral-Polymer Composite Formation and Purification for Guided Bone Regeneration and New Generation of Implant Fabrication

Tech Area / Field

  • CHE-POL/Polymer Chemistry/Chemistry
  • MED-OTH/Other/Medicine

Status
8 Project completed

Registration date
03.06.1999

Completion date
29.12.2004

Senior Project Manager
Weaver L M

Leading Institute
State Research Institute of Organic Chemistry and Technology, Russia, Moscow

Supporting institutes

  • Research Centre for Technological Lasers, Russia, Moscow reg., Troitsk

Collaborators

  • Johns Hopkins University, USA, MD, Baltimore\nTechnical Center Ferro Corporation, USA, OH, Independence

Project summary

The goal of the project - the development of the biostable and biodegradable porous mineral-polymer composite materials for guided bone regeneration and fabrication of a new generation of implants for orthopaedic, neuro- and maxillofacial surgery and dentistry.

The modification of a structure both properties of biopolymers and bioactive mineral-polymer composites by supercritical fluid processing is a priority of author's team from NICTL RAN in cooperation with the specialists from Nottingham University (UK) and Ferro Corporation (USA).

The problem of the strong interface formation between organic (polymers) and inorganic (hydroxyapatite - HA, tricalcium phosphate - TCP) substances is extremely actual today. This bonding can be made by direct chemical bond formation between components or by “grafting” of organic molecules with active molecular groups, capable hereinafter to form chemical bond with inorganic particles. In the project it is offered to proceed “grafting” under supercritical conditions. Besides that we propose to use laser activation of the polymer surface and direct impregnation of inorganic microparticles into the polymers by laser ablation.

The program of research consists of four stages:

1. Development of methods and processes for homogeneously filled (with an optimum ratio HA/Polymer) biostable and biodegradable (bioresorbable) of mineral-polymer composite fabrication, possessing required bio-mechanical properties.

2. Study of supercritical extraction of the toxic impurities and technological additives from polymers and mineral-polymer composites to enhance their biocompatibility.

3. Development methodological, informational and software packages on a problem of supercritical fluid interaction with the biopolymers for determination the optimum conditions of a new composite processing.

4. Study of the complex interaction of these materials with the body (from initial cell culture reaction to the long-term behaviour of the osteointegrated implant or regenerated new bone site) following by search and synthesis (based upon the experimental results) of the optimum polymer composition with well controlled and desirable properties.

During implementation of the project the following outcomes will be obtained:

· Processes of formation of homogeneously filled biostable and bioresorbable mineral-polymer composites will be developed and optimum conditions of the technological procedures will be determined.

· As a result of studies of intermolecular interactions of multicomponent polymeric and mineral-polymer systems possessing various chemical structure with a supercritical carbon dioxide, the experimental samples of synthetic bone with the structure, morphology and biomechanical properties very similar to that found in natural bone materials will be produced.

· The optimum bioactive polymeric compositions with specific required properties will be developed.

· Experimental samples of porous mineral-polymer composites for guided bone regeneration and a new generation of implants for orthopaedic, neuro- and maxillofacial surgery and dentistry will be produced.

· Methodological, informational and software packages for identifying samples suitable for supercritical extraction, analysis and prediction of optimal conditions for supercritical fluid processing of a wide range of a polymer materials will be developed.

The outcomes of earlier conducted by project authors researches in the given area are published in the following items:

1. E.N.Antonov, B.N.Bagratashvili, V.K.Popov, E.N.Sobol, K.Parker, T.Parker, S.Howdle. "Films of bioactive ceramic produced by laser ablation of apatites", J.Advanced Materials, 2, 3, 228-237, 1995.

2. E.N.Antonov, V.N.Bagratashvili, V.K.Popov, E.N.Sobol, S.M.Howdle. "FT-IR determination of the stability of laser deposited apatite coatings in phosphate buffered saline solution using Fourier transform infrared (FTIR) spectroscopy", Spectrochemica Acta, Part - Molecular and Biomolecular Spectroscopy, A52, 123-127, 1996.

3. T.L.Parker, S.M.Howdle, E.N.Antonov, V.N.Bagratashvili, V.K.Popov, E.N.Sobol, C.J.Roberts. "Biocompatibility of laser-deposited hydroxyapatite coatings: correlation of coating parameters with cell behavior", Cellular Engineering, 1, 2, 91-96, 1996.

4. V.K.Popov, E.N.Antonov, V.N.Bagratashvili, Yu.P.Sukhanov, A.I.Volozhin, A.B.Shechter, S.M.Howdle, D.Jones. Toxic additive extraction from polymer dental implants using supercritical carbon dioxide, Medical & Biological Engineering & Computing, 35, Part I, p.606, 1997.

5. V.K.Popov, E.N.Antonov, A.I.Volozhin, A.G.Karakov, Y.P.Sukhanov, A.B.Shehter, M.Carrott. Tissue reaction on acrylic polymers modified by supercritical carbon dioxide extraction, Stomatologia (Russ.), 77, 2, 1998.

6. A.I.Volozhin, I.A.Omarov, A.P.Voronov, V.K.Popov, E.N.Antonov. Improving the biocompartibility of polymethylmethacrylate dentures by hydroxyapatite, Stomatologia (Russ.), V.76, 5, pp.40-43, 1997.

7. E.E.Said-Galiev, L.N.Nikitin, Y.P.Kudryavtsev, A.L.Rusanov, O.L.Lependina, V.K.Popov, S.M.Howdle, M.Poliakoff. Impregnation of organometallic compounds to polymers using fluids in supercritical state, Chemical Physics (Russ.), V.14, 9, pp.190-192, 1995.

8. E.N.Sobol, V.N.Bagratashvili, A.E.Sobol, S.M.Howdle. Kinetics of supercritical impregnation of polymers, DAN (Russ.), 356, 6, pp.77-780, 1997.

9. E.N.Sobol, V.N.Bagratashvili, V.K.Popov, A.E.Sobol, E.E.Said-Galiev, L.N.Nikitin. Kinetics of the diffusion of organometallic solutions to the polymers in supercritical carbon dioxide, J.Phys.Chem.(Russ.)., 1, pp.28-31, 1998.

10. A.P.Krasnov, E.E.Said-Galiyev, L.N.Nikitin, O.V.Afonicheva, I.O.Volkov, V.K.Popov, V.N.Bagratashvili, A.D.Aliev. Friction and wear of the polyarylate impregnated by Cu-hexafluoroacetylacetonate in supercritical CO2-solution, Friction and Wear (Russ.), V.19, 1, pp.90-96, 1998.

11. V.K.Popov, V.N.Bagratashvili, A.P.Krasnov, E.E.Said-Galiyev, L.N.Nikitin, O.V.Afonicheva, A.D.Aliev. Modification of tribological properties of polyarylate by supercritical fluid impregnation of copper(II) hexafluoro-acetylacetonate, Tribology Letters, 1998 (in press).

12. V.K.Popov, S.M.Howdle, F.S.Mandel. Supercritical fluid assisted production of synthetic bone composites, Proc. of 5th Meeting on Supercritical Fluids, Materials and Natural Products Processing (Nice, France), 1, pp.45-50, 1998.

13. A.N.Fedotov, A.P.Simonov, V.K.Popov, V.N.Bagratashvili. Dielectrometry as a method to study solubility of polar compounds in supercritical fluids, J.Phys.Chem.(Russ.)., V.70, 1, p.166-168, 1996.

14. A.N.Fedotov, A.P.Simonov, V.K.Popov, V.N.Bagratashvili. Dielectrometry in supercritical fluids; a new approach to the measurement of solubility and study dipole moment behavior of polar compounds, J.Phys.Chem., 101, 15, pp.2929-2932, 1997.

15. A.N.Fedotov, E. A. Sinevich, A. P. Simonov. Intermolecular Interaction of Supercritical Carbon Dioxide with Polymers of Different Classes, J.Phys.Chem. (Rus.), 71, 11, pp.2099-2102, 1997.


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