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Newborn contamination by Staphylococcus

#T-2022


Study of infectious diseases Staphylococcus etiology and antibiotics sensitivity among newborn in the Gorno – Badakhshan Autonomous Oblast (GBAO) of Tajikistan

Tech Area / Field

  • ENV-EHS/Environmental Health and Safety/Environment

Status
3 Approved without Funding

Registration date
04.06.2012

Leading Institute
Service of Sanitary Epidemiological Surveillance of the Department of Health of the Gorno-Badakhshan Autonomous Oblast (GB), Tajikistan, Khorog

Supporting institutes

  • The Regional Healthy Life Style Centre, Gorno-Badakhshan Autonomous Oblast of the Department of Health of the Tajikistan, Tajikistan, Khorog\nRegional Central Hospital of the Department of Health of the Gorno-Badakhshan Autonomous Oblast (GBAO), Tajikistan, Khorog

Project summary

Background: Anthropogenous and ecological factors lead to changes (as a rule, towards reduction) reserves of health at inpidual and population levels, to increase of degree of physiological pressure, growth of pathologies and occurrence of new forms of "ecological" illnesses. Accumulating on other risk factors, including causal, ecological factors have resolving an effect on development of some diseases.
Gorno – Badakhshan Autonomous Oblast (GBAO) is region of Tajikistan, landlocked mountainous area. Starting from November up to May for already six months is isolated from national level due to heavy snowing and bad road connection. Community during this period is blocked; region is poor with infrastructure, equipment and trained personnel. Capital of GBAO is Khorog which is boarder with Afghan mountainous part.
The Project aim: The purpose of the given project is to study influence of anthropogenesis environmental contamination by Staphylococcus in newborn after birth in the maternity home, antibiotics sensitivity of Staphylococcus and possibility of realization of ecology - microbiological monitoring of environment by revealing the priority anthropogenesis factors of influence on biological characteristics of staphylococcal autophlora and microbiological indicators as markers for environment.
Current status: At this date estimations not have been made due to shortage of laboratory materials, but obviously we can say that newborn discharged from RCH have sepsis, skin inflammations and respiratory diseases. In many cases prescribed antibiotics are not available and the other reason laboratory is not performing antibiotics sensitivity which in his turn leads to the deterioration of newborn status and further death.
The project’ influence on progress in this area If this minor experiment is successful and can get estimation for which type of Staphylococcus is circulating and of course we will study antibiotic resistance and also these data will allow SSES to implement preventive measures to control spread of infection due to Staphylococcus, which means that the decision of these questions allows all complexes of ecological and hygienic characteristics, to reveal ecologically the most adverse territories, carry out mapping and to develop scientifically well-founded recommendations on optimization of the environment conditions.
The participants’ expertise The scientists taking part in the project have considerable experience in the investigation of Staphylococcus and also if would have proved data can fulfill required international recommendations to prevent spread of Staphylococcus in the maternity home, also allow publication of the study results and participation in the international conferences. The other institutions involved will provide activities towards increasing knowledge and skills of health workers and community in preventing infectious diseases caused by Staphylococcus and its sensitivity to the antibiotics.
Expected results and their application The project will result in a better understanding of the situation and epidemiology of Staphylococcus and its sensitivty to antibiotics in GBAO and Tajikistan. This better understanding will help responsible scientists and institutions on going national control programmes and building capacity in GBAO and Tajik institutions to carry out their mandates for Staphylococcus and prescribed antibiotics control in the country. This project is an interlinked series of fundamental investigations, combined with capacity building, with the aim of generating information and surveillance on Staphylococcus, including activity on antibiotics sensitivity in the GBAO and Republic of Tajikistan. The data obtained in the project should lead to better implementation of control measures and ddefine the high importance of ecologo-microbiological monitoring for the development of target programs to decrease in adverse influence of environment factors.
The approach will be developed to association of the data of the ecologo-hygienic analysis of territories and results of research of Staphylococcus characteristics in the uniform database, allowing conduct situation analysis of cause relationships and effect between variability of biological properties staphylococcal autophlora and separate environment factors, including study on antibiotics sensitivity.
Necessity of carrying out is proved by regional microbiological researches of the staphylococcal flora serving as the indicator for state environment, for developing a regional ecological policy on decreasing influence of anthropogenous factors on population health and procurement of necessary antibiotics.
Territories with unsatisfactory sanitary and hygienic and microbiological conditions will be defined. On the basis of this data it is possible to develop and confirm an order of interaction of hygienic and microbiological monitoring.
Meeting the ISTC goals and objectives This project includes integration of former weapons scientists from GBAO and Tajikistan into the international scientific community and fosters self-sustaining civilian activities. It supports laboratory capacity building and practical, applied research in Tajikistan and should assist in mutual collaboration by way of sharing scarce material and exchange of information. The collaborators will benefit from the project because GBAO and Tajikistan have positive material that is useful for validation studies at this institute. Numerous tests have been developed at modern world and the project will assist in the development and validation of these new and improved diagnostic procedures.
There are numerous tests available with equally broad ranges of test sensitivity and specificity, which lack usefulness in diagnosing disease and relapses. Data obtained from the assays will be unique, will be used to validate reagents and recommend methods to rapidly and accurately diagnose of Staphylococcus and its sensitivity to antibiotics.
Information will be acquired regarding Staphylococcus under investigation with the purpose of defining the real epidemiological situation. One objective is to understand and disseminate information on prevention of Staphylococcus realities to human health and its treatment. The success of this project will meet the ISTC goals of supporting education and public awareness of Staphylococcus as well as providing preventive programmes for control of Staphylococcus and other microbal infections, including antibiotics sensitivity.
Scope of activities:
- Enhancing possibilities for diagnostics of environment’ means and the human being
- Determine microbiological indicators of Staphylococus in nosopharynx mucous membrane influenced by chemical pollutants in newborn
- Determine sensitivity to different types of antibiotics
- A hygienic estimation of anthropogenesis pollution of atmospheric air in maternity wards
- The hygienic analysis of drinking water quality in maternity wards
- Development educational materials for health workers and mothers
Role of Foreign Collaborators/Partners Collaborators would need for providing any assistance in term of making visits in order to advice equipment needs, reagent supply, test methodology and storage of material, on safe handling of material and decontamination procedures in the laboratories, guide on quality control requirements and international standards, support in capacity building, advise on long term storage of DNA, cultures and on international transport practices, act as laboratory testing and SOP consultants, confirm tests and troubleshoot as necessary, recommend databases / archiving methods for material and results, advise on sustainability after the project, e.g. lab management, procurement, roles, responsibilities and audits and provide guidance to the participants of the project in attending international conferences and preparation for publication.
Technical approach and methodology The main innovation of the Project work is prevention of the diseases caused by Staphylococcus and reducing infant mortality as this is the main indicator of the Millennium Development Goal. Moreover project will support clinicians prescribe reliable and safe antibiotics to treat cases and also reduce mortality.
Result of this project will assist community of GBAO region, which is mountainous, isolated during six cold months from national level and low capacity of laboratory diagnostic technique to get proper treatment and also supports clinicians to improve their knowledge and skills in treating infections caused by Staphylococcus.
GBAO hospital overall provide medical assistance to Afghan community too and also opportunity to learn more on infectious diseases meeting in neighboring community.


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