Development and Research of New Biomaterials on the Basis of Polymers and Metal-Polymer Nanocompositions
Tech Area / Field
- BIO-CGM/Cytology, Genetics and Molecular Biology/Biotechnology
- CHE-POL/Polymer Chemistry/Chemistry
3 Approved without Funding
National Academy of Sciences of Kyrgyzstan / Institute of Chemistry and Chemical Technology, Kyrgyzstan, Bishkek
- Universita Degli Studi di Roma "Tor Vergata" / Dipartimento di Scienze e Tecnologie Chimiche, Italy, Rome\nCranfield University / School of Applied Sciences, UK, Bedford\nUniversity of Oslo / Department of Pharmacy, Norway, Oslo
Project summaryThe goal of the present project is to fabricate hybrid multifunctional nanocomposites, including metal-containing, based on natural biological polymers (pectin and humic substances). It is focused on the creation of novel highly effective biologically active formulations of macromolecular nature to be ultimately clinically applied, namely in magnetodirected drug delivery systems, hybrid nanoassemblies with bactericidal, antitumor and tumor chemosensitizing activities. As the result of the project implementation novel biomaterials based on metal-polymer nanobiocomposites will be developed.
This project is therefore in the field of the design of bionanomaterials and nanobiomaterials that are to be used as substances for biological and pharmaceutical preparations. Namely, incorporation of natural (biological) materials into nanocomposites (bionanomaterials) and the application of nonbiological nanomaterials in medicine (nanobiomaterials). Biological natural polymers as pharmaceutical substances and drug carriers have many advantages, including good biocompatibility, nontoxicity, and adjustable controlled release properties. We will focus on two kinds of biomaterials, pectin and humic substances.
A variety of pharmacological properties of pectins suggest them as a potential source of new drugs. The majority of antiblastic drugs produce toxic effect on actively regenerating cell systems, which limits their effective use. Therefore, the search for new means increasing selective effect of cytostatics is a pressing problem in tumor chemotherapy. Pectins have a wide spectrum of physiological activity, including immunomodulating and gastroprotective action. A property of great importance is the anticarcinogenic and/or antimetastatic effects of pectins.
The most striking feature of humic materials in the context of biomaterials technology is constellation of such unique properties as non toxicity, biocompatibility, resistance to biodegradation, and polyfunctionality. As a result, these materials can be competitive in the market of biobased products, especially, biopreparations and green special chemicals (dispersants, flocculants, chelators, etc.). The development of advanced fractionation techniques is also a part of this project, and is expected to be of particular importance for the refining the biomedical properties of HS inherent in the minor fractions.
In order to reach the goal it is necessary to solve the following tasks:
- To isolate and characterize of native pectin and humic substances;
- Fabrication of nanocomposites based on natural biological polymers (pectin and humic substances);
- Characterization of the structures of humic and pectin nanocomposites;
- Estimation of the antibacterial and antioxidant potential of the bionanocomposites;
- Estimation of the anticancer and chemosensitizing potential of the bionanocomposites;
- Evaluation of possible toxic properties of the nanocomposites;
- Scale-up of technology for preparating effective nanoscale pectin and humic derivatives.
Specifically new point is the development and optimisation of the methods for fabrication natural polymer-based preparations by the indices of efficacy and specificity of their pharmacological effect with respect to tumors. For the first time for this purpose it is planned to use nanoscale derivatives along with native pectin and humic substances. It is necessary to note, that the development of non-specific and selective pectin and humic preparations will be provided for the first time on the quantitative basis, using the dependence “structure- property”. Performance of the studies within the proposed project will allow to provide qualitative transition from the theory to practice of the application of natural polymers and their nanoscale derivatives as pharmacological substances for anticancer therapy.
Publications relevant to the project are listed below:
- Jorobekova Sh. 1986: Macro-ligand properties of humic acids. Frunze, Ilim, 195 pp.
- Ashubaeva, S.D., Kozlova I.I. 1991: Metalcomplex derivatives of pectins and their use. Ilim,, 94 p.
- Aimukhamedova G.B., Aliyev D.E., Shelukhina N.P. Properties and application of pectin sorbents. Ilim, 1984, 116 p.
- Jorobekova, Sh., Kydralieva, K.A, Alexandrov, V.G. 1998: Development of new humic-based products and their application in agricultural and biopharmaceutical sectors. In: Proc. of ISTC Seminar. Bishkek, 98-101.
- Aymukhamedova G.B, et al. K polygalacturonate with chemiosensitizing tumor effect. Kyrgyz pre-patent, 318, 1999.
- Ushbaeva, GG, et al. 2002:The possibility of the use of plant-based biopolymers for the tumor corrective therapy. In: Materials Int. Conf. "Safety and life quality in big city" Almaty, 134-138.
- Aymukhamedova GB, et al. 2003: Metalcomplexes of piroglutamin acid and polygalacturon as new anticancer compounds with a wide range of physiological and therapeutic action. Journal of Kyrgyz National University, 3 (1), 106-112.
- Aymukhamedova MB, et al. Ni polygalacturonate with chemisensitizing tumor effect. Kyrgyz Patent, 712, 2004.
- Aymukhamedova, M.B, et al. Co polygalakturonate with chemisensitizing tumor effect. Kyrgyz Patent, 734, 2004.
- Pomogailo A.D., Розенберг А.S., Uflyand. 2000: Nanoparticles of metals in polymers, М.: Chemistry, 2000, 672 p.
- A.D. Pomogailo, V.N. Kestelman. 2005: Metallopolymer nanocomposites. Springer, Heidelberg, 563 p.
- Pomogailo A.D. 2006: Metallopolymer Nanocomposites. Macromolecular metallocomplexes as precursors for polymer, polymer-inorganic and bionanocomposites. Chapter in book “Metal and Metalloid Containing Macromolecules”, ed. by Ch. Carraher, Jr., C. Pittman, Jr., Abd-El-Aziz, M. Zeldin, and J. Sheats, Wiley-Interscience, John Wiley and Sons, Inc., New York, 7. Chapter 4, 87-220.
- A.D. Pomogailo, A.S. Rozenberg, G.I. Dzhardimalieva. 2006: Controlled pyrolysis of metal-containing precursors as a way for syntheses of metallopolymer nanocomposites. Chapter in Book: “Metal-Polymer nanocomposites” (Eds. L. Nicolais, G. Carotenuto), Wiley, 75-122
- A.D. Pomogailo, V.N. Kestelman. 2005: Nanobiocomposites. Chapter 9 in book “Metallopolymer nanocomposites”, Springer