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Thyroid Diseases after Exposure in Childhood

#2865


Risk Estimation of Thyroid Diseases in Later Life Associated with Technogenic Exposure to Iodine-131 in Childhood

Tech Area / Field

  • MED-DIS/Disease Surveillance/Medicine
  • MED-RAD/Radiomedicine/Medicine
  • ENV-EHS/Environmental Health and Safety/Environment

Status
3 Approved without Funding

Registration date
14.08.2003

Leading Institute
A.I. Burnazyan Federal Medical and Biophysical Center / Chelyabinsk Branch, Russia, Chelyabinsk reg., Oziorsk

Supporting institutes

  • NPO Mayak, Russia, Chelyabinsk reg., Oziorsk

Collaborators

  • Karolinska Institute, Sweden, Stockholm\nForschungszentrum für Umwelt und Gesundheit GmbH (GSF) / Institut für Strahlenschutz, Germany, Neuherberg

Project summary

It is known that the thyroid is highly radiosensitive especially in childhood. This information was obtained based on external exposure effects. At the same time information on effects due to incorporated iodine is limited by single studies, and radiation risk due to iodine-131 incorporation still hasn’t been correctly estimated given the peculiarities of exposure dose distribution in the thyroid and lack of verified estimations of radioactive doses per thyroid.

Main project purpose is the estimation of radiation risk of thyroid diseases in later life associated with technogenic exposure due to iodine-131 in childhood. In order to achieve this purpose thyroid status will be studied in residents of Ozyorsk (Ural region) exposed to various radiation doses per thyroid mostly due to incorporated iodine-131 in childhood from gaseous-aerosol releases produced the nuclear enterprise “Mayak” PA. It is planned to perform the reconstruction of exposure doses and to study dose-dependence of thyroid diseases incidence and structure to quantify the radiation risk coefficients for deterministic and stochastic effects on thyroid due to technogenic exposure in childhood. The present study will allow to clarify association between thyroid pathology and effects on thyroid due to iodine-131.

State-of-the-art methods including theoretical, experimental, calculation, medical, statistical, laboratory, and scientific - technical approach as well as technical means providing required accuracy and significance of final results will be used in this project.

30 scientists and technical engineers experienced in the fields of external and internal dosimetry, dose reconstruction, medical examination of the thyroid and epidemiology will be engaged in the project as main personnel. The implementation of the project will allow scientists and specialists of “Mayak” PA and SUBI once related to weapons research to reorient their skills on peaceful activity. Results of studies could be useful for development of criteria for safe residence next to active nuclear and power plants both in Russia and abroad in order to minimize late effects from possible nuclear accidents.

Exchange of information and cross-check of research results will be performed, joint seminars held, and material assistance provided to project participants to give them opportunity to attend international seminars during foreign collaboration.


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