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Progenitors of Antiviral and Tuberculostatic Preparations

#G-1748


“Investigation by Prof. T.Khoshtaria's Method of the Synthesis of Tetracyclic Systems of Izomeric 1H-benzo[b]thiophene(furo)-indoles, 1H-benzo[b]thiophene(furo)-benzimidazoles and 6α-pirono-1h-indoles – with Antiviral and Tuberculostatic Acrivities (Synth

Tech Area / Field

  • BIO-CGM/Cytology, Genetics and Molecular Biology/Biotechnology
  • MED-DID/Diagnostics & Devices/Medicine

Status
3 Approved without Funding

Registration date
29.04.2009

Leading Institute
Georgian Technical University, Georgia, Tbilisi

Collaborators

  • Southern Research Institute, USA, AL, Birmingham\nUniversity of Alberta / Faculty of Pharmacy and Pharmaceutical Sciences, Canada, AB, Edmonton\nErweiterte Realschule Saarbrücken -Güdingen, Germany, Saarbrücken

Project summary

The basic statistics on the modern global tuberculosis problem is well known: one third of the world's population are considered to be infected; 6 millions of new cases are registered every year; TB accounts for 20% of adult and 6% of infantile early deaths. The ever-growing resistance of tuberculosis to medicines undoubtedly gives rise to the demand for creating new antituberculous remedies.

There also exists an equally urgent need for producing other new antiviral preparations in view of a permanent threat of flue epidemic.

In September, 2002 an international symposium dedicated to the current tuberculosis problems was held in Bangalore, India. Prof. T. Khoshtaria attended the symposium as an invited speaker. Professor PatrIR D.Brenner delivered a plenary lecture at the symposium, in which he quoted the data of WHO on the problems of tuberculosis, and called researchers to develop a new generation of preparations because of increased resistance of tuberculoso to the existing preparations, and was supported by all the participants of the symposium. This stimulated Prof. Khoshtaria's team to switch over their efforts to the development of new antituberculous preparations.

Condensed tetracyclic indole-containing unsubstituted compounds such as 1Н-benzo[b]thiophene-indoles, 1Н-benzo[b]furo-indoles, 1Н-benzo[b]thiophene(furo)-benzimidazoles and tricyclic 6-α-pyrono-1H-indole were selected as basic compounds for the creation of the new generation of antituberculous preparations.

The basic data obtained within the framework of the project will further make it possible to construct new heterocyclic systems (e.g. dioxodihydro-derivatives including carboxyl-containing ones) that can also be used as drugs of the new generation revealing antitumoral, antiviral (against HIV) and hypotensive activity, to treat cardiovascular diseases and diabetes an so on.

All the compounds to be obtained by the Georgian team headed by Prof. Khoshtaria will be forwarded to the collaborators for screening and pertinent studies. The collaboration will promote the integration of the Georgian scientists into the international scientific community.


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