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Biological Activity of Chemical Pollutants

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Developing a System for Determination and Prediction of the Biological Activity of Chemical Compounds and Ensuring an Environmental and Chemical Safety on the Territory of the Republic of Belarus

Tech Area / Field

  • BIO-OTH/Other/Biotechnology
  • ENV-EHS/Environmental Health and Safety/Environment

Status
3 Approved without Funding

Registration date
17.11.2000

Leading Institute
International Sakharov Environmental University, Belarus, Minsk

Supporting institutes

  • National Academy of Sciences of the Republic of Belarus / Institute of General and Inorganic Chemistry, Belarus, Minsk\nBelarussian State University, Belarus, Minsk

Collaborators

  • Yale University / Bridgeport Hospital, UK, Bridgeport\nUniversite de Picardie Jules Verne, France, Amiens\nKingston University / Faculty of Science, UK, Kingston\nLudwig-Maximilians-Universität / Strahlenbiologisches Institut, Germany, Munich\nBrown University / Department of Pathology, USA, RI, Providence

Project summary

The aim of the Project is to develop a complex system of theoretical and experimental screening of the activity of chemical compounds (CC), their combinations and influence on a number of key systems of organism activity, to evaluate and forecast ecological safety over different territories.

At present the system of determination of CC influence on the organism includes testing of their toxicity and influence on certain aspects of exchange processes. As a rule CC are tested to reveal one type of reaction in an organism, not taking into account other types of biological effects of the compounds. Such testing does not give an integral picture of the interference of CC combinations in the organism activity. It is for this reason that there is a need to create a complex system to reveal basic biological effects of each CC and to forecast their activity in the organism. In order to solve the problem a complex data-analytical system should be created, the like of which is not known in the Republic of Belarus at present.

The project aims to enrich information on chemical transformation in the biosphere and biological activities of CC, to forecast the consequences of the pollutant’s influence on living systems and its communities, to seek protecting substances, and to create a database. The created data-analytical system will considerably improve the existing CC database system in the Republic of Belarus in terms of their toxicity and biological influence on the organism. The obtained results on biological CC activity and protecting substances may be applied to forecasting and liquidation of ecological disasters over any territory.


The duration of the project is three years. The project includes the following stages:
1. Elaboration of analytical methods for testing CC on biological activity;
2. Analysis of the environment and testing the influence of CC on living organisms;
3. Analysis and interpretation of obtained results and development of the data-analytical system to forecast the ecochemical situation over different territories.

Total Project efforts is 584 man*mths and the effort of weapon scientists totals 297 man*mths.

Testing of CC and their combination will be conducted using modern analytical, electro-chemical, immunological, molecular-biological, physiological, biochemical and other methods. When solving tasks 1 and 2 of the project, on creation of a test system of CC biological activity and systems for estimation of environmental pollution with the help of biological tests, the following major points will be taken into account:


– sensitivity to a wide range of xenobiotics and pollutants, especially toxigenic to man;
fast test-response and reliability of registration;
availability and simplicity of the preparation of a test-object;
the absence of disorders in normal physiological functions and the possible standardisation of a test-object;
automated collection and processing of information

All these points will form the basis for the creation of methods of CC analysis on biological activity. Moreover, analysis of the environment and testing of the influence of CC on living organisms will also be conducted.

When solving task 3 a software complex will be developed for theoretical screening. It is based on the following three key points:


creation of CC database, containing descriptive information on the test results on selected tests;
development of an adequate language to present CC. It is necessary both for database formation and also for subsequent theoretical and calculation testing;
creation of the software complex.

The data-analytical system, based on these three points, will be used to forecast the ecochemical situation over different territories of the world. This system will be estimated as an invention. Recent research, conducted in laboratories at ISEU, BSU and IGICh, are ecologically oriented and can be used as the basis for successful project fulfilment.

Foreign collaborators are involved in realisation of the project proposal. Information exchange, shared use of certain equipment and/or test and sample materials are provided in the course of project implementation; assistance for the project participants to join international meetings is also provided.

Professor A. Beck and Doctor A. Flowers will render consultative support at monitoring and analysis of contaminated environmental samples (soil, water, air, plants) and at finding methods of its rehabilitation. Professor Daniak and Professor Lengfelder will render consultative support at estimating the medico-biological effects of CC, arranged effects, chemical compounds and ionising radiation. Professor Zhitkovich and Professor Laberche will co-ordinate molecular-biological research on the influence of chemical compounds on humans, animals and plants.


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