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Transport of Neurotropic Peptides into the Brain

#3856


Neurodegenerative Diseases: Nanotechnological Approach to the Treatment and Prophylaxis Based on Targeted Transport of Neurotropic Peptides into the Brain

Tech Area / Field

  • BIO-CHM/Biochemistry/Biotechnology
  • MED-DRG/Drug Discovery/Medicine

Status
3 Approved without Funding

Registration date
31.03.2008

Leading Institute
Ministry of Health / The First Moscow State Medical University named after I.M.Sechenov, Russia, Moscow

Supporting institutes

  • Institute of Immunological Engineering, Russia, Moscow reg., Lyubuchany

Collaborators

  • University of London / King's College London, UK, London\nJohann Wolfgang Goethe-Universität / Institut für Pharmazeutische Technologie, Germany, Frankfurt am Main

Project summary

The aim of the Project

The main aim of the Project is to create a new generation of preparations for the treatment of neurodegenerative diseases of the Central Nervous System (CNS) based on nanocarriers from natural and synthetic polymers containing a nerve growth factor.

Now, at general world tendency to life-span increase, pharmacotherapy of the diseases of elderly and senile age gains more and more importance. Neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, etc.) belong to their number. Applied at present, drug preparations eliminate mainly disease symptomatics not preventing the neurodegenerative process subjacent of pathology. Besides, a prolonged application of such preparations is inevitably accompanied by multiple side effects. In connection with the above, development of principally new approaches to their prevention and treatment, as well as construction of a new generation of preparations based on nanotechnologies are required.

The Project participants first found the ability of polymer nanoparticles to relieve the penetration into the central nervous system of one of neurotrophic peptides – nerve growth factor. For this purpose, a more detailed study of regularities of transport of high molecular peptides with neurotrophic activity using various transport systems, as well as a development of procedures for peptide insertion into polymer carriers and a study of sorption properties of such carriers are required. Besides, it is necessary to study qualitative and quantitative characteristics of the transport efficacy of different nanocarriers using immunoenzyme assay and chromatography techniques following with a study of pharmacologic activity and toxicity of preparations containing nerve growth factor in composition of the nanotransport system.

Project participants have a wide spectrum of scientific knowledge and a profound experience in the studies of the field of nanocarriers. The scientific research collective comprises 8 doctors of science, 6 candidates of science, graduate students and undergraduates.

Beginning since 1994, the studies in the field of nanocarriers became the priority-oriented ones for the Project participants. Besides, the principal direction was an amplification of the subject on a possibility of their application in medicine. The results of the studies of the applied and fundamental importance were presented in numerous publications and 2 patents. The list of publications of the Project participants on the Project subject is enclosed. A material and technical base for obtaining and study of nanoparticles providing obtaining of reliable results and successful Project completion is totally equipped.


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