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Production of Biologically Active Copolymers

#2159


The Elaboration of Technology for Synthesis of N-vinylpirrolidone/vinylpiridine Copolymers and Producing New Biologically Active Substances Having Immunostimulating Properties on Their Basis

Tech Area / Field

  • CHE-POL/Polymer Chemistry/Chemistry
  • AGR-VTH/Vaccines and Theraupetics/Agriculture
  • BIO-IND/Industrial Biotechnology/Biotechnology

Status
3 Approved without Funding

Registration date
02.04.2001

Leading Institute
Lomonosov Academy of Fine Chemical Technologies, Russia, Moscow

Supporting institutes

  • Pokrov Plant of Biopreparations, Russia, Vladimir reg., Pokrov

Collaborators

  • Universita' Degli Studi di Trieste / Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Italy, Trieste

Project summary

At present one of the most actual problems of modern veterinary and virology is a problem of prophylaxy and treatment of such world-wide distributed contagious diseases of farm animals as carbuncle and classical murrain of swains.

Now the main method of prophylaxy and treatment of the diseases for farm animals is the obligate vaccination combined with antibiotic treatment. The quantity of the actions causes great financial expanses during which some types of immunization has to be carried out at two steps. For instance, Pokrov factory of biosubstances produces 10-12 mln. of vaccine doses against carbuncle and 5 mln. vaccine doses against classic murrain of swains a year.

Another problem of mass vaccination is higher than usual sensitivity of many farm animals to vaccine substances. Thus edema and death are quite often the result of a vaccine injection to gouts.

A way to solve the problems of vaccination might be the using of the vaccination in combination with immunostimulating substances. This will enable not only to reduce the financial expenses through decreasing the injected vaccine doses but also to increase the efficiency of immunization by lowering the immune stress of vaccination.

To make success in the direction the elaboration of new biologically active substances has to be done. From this point of view the polymers having wide spectrum of their own physiological activity may be of particular interest. The specific physiological properties of the polymers are defined by their macromolecule nature and make a chance to create new biologically active substances having unique characteristics.

The contemporary practice shows that the most of the present-day methods of synthesis as well as the polymers by their own do not quite satisfy the modern criteria of veterinary and virology. Thus, the low monomer conversions, irregularity of chemical structure as well as nonreproductivity of composition and mass molecular distribution which likely govern the properties of the biologically active polymers courses significant complications in technology, veterinary treatment and ecology.

That is why one can see that much attention is paid now to develop new methods of polymer synthesis which have no the drawbacks mentioned. Another question rise in the context of the new investigations is the question of ecology safe methods of synthesis.

One of the polymers fitting the mentioned criteria is poly-N-vinylpyrrolidone widely used as a prolongation and anti toxicosis agent. The copolymers based on N-vinylpyrrolidone are known ones having their own physiological activity. Of the mentioned copolymers we consider the copolymers of N-vinylpyrrolidone (NVP) with vinylpyridines (VP) synthesized in our research group the most promising. The prior biological tests of the NVP/VP copolymers carried out by the Prof. Kedik’s group have demonstrated the immunogenic activity of the systems. It has been found that production of new generation preparations on the basis of NVP/VP copolymers requires a radically new approach to the technology of their synthesis, which will provide the strictly specified compositional distribution of the polymer chains as well as the narrow mass molecular distribution with well defined molecular mass.

The objective of the suggested project is elaboration of technology for synthesis of NVP/VP copolymers having well defined properties and producing the biologically active preparations on their basis. The project relates to the category of Applied Research, Technology Development and Technology Demonstration.

The development of the project has to involve the detailed study of every step of the technology process. It might be the steps of detailed study of the copolymerisation process using the laboratory equipment; developing the principles of the pilot technology for NVP/VP copolymers synthesis; development of new technology for NVP/VP copolymers by montage and checkout of a pilot plant; choosing the control methods for the copolymerization, for separation and drying of the products; choosing the apparatus and adopting their constructional features to the process with regard for the scaling when going from the laboratory to the pilot synthesis equipment; producing the copolymers in the amount enough for the extend tasting biological experiments; testing biological experiments by the use of cell models, laboratory animals and farm animals in order to verify the harmlessness and biological activity of the copolymers; formation of the file of the papers needed for the further investigations directed to incorporation of the biologically active copolymers into the veterinary practice. In accordance to the primary ISTC objective the submitted project provides the weapon scientists the opportunity for peaceful scientific and research activity aiming to reverse the direction of their interests. More than 60% of scientists involved in the project are employed by Pokrov factory of biosubstances. They are known as experts in bacteriological weapon production in the past. The participation of the scientists of Pokrov factory in the project will support the conversion of the weapon factory to the market economy serving the civil needs.

The project has attracted well known experts in biologically active polymers from the countries being the Parties to ISTC Agreement. They are ready to collaborate with our group within the framework of the project. The field of collaboration may be wide: participation in joined seminars and workshops for discussion and coordination of the work at all steps of the project; expert estimation of current work and/or technical reports; performance of some collaborative experiments. All the actions planned will definitely contribute into the objective of ISTC to integrate the scientists of former Soviet Union in international scientific society.

Developing the project will support the applied research and technology development of ecologically pure process, which makes it extremely important from the point of environmental protection. The realisation of the project will help to solve the actual virology and veterinary problem of prophylaxy and treatment of carbuncle and classical murrain of swains.


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