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Membranes for Medicine and Environmental Chemistry

#1891


Gas-Permselective Film Membrane Materials on the Basis of Carbo-Functional Oligo-Organosiloxanes for Public Health and Personal Chemical Dosimetry

Tech Area / Field

  • MAT-ELE/Organic and Electronics Materials/Materials
  • CHE-ANL/Analytical Chemistry/Chemistry
  • CHE-POL/Polymer Chemistry/Chemistry
  • ENV-EHS/Environmental Health and Safety/Environment
  • ENV-MIN/Monitoring and Instrumentation/Environment
  • MED-OTH/Other/Medicine

Status
8 Project completed

Registration date
31.05.2000

Completion date
04.02.2004

Senior Project Manager
Zalouzhny A A

Leading Institute
Lomonosov Academy of Fine Chemical Technologies, Russia, Moscow

Supporting institutes

  • Kazan State Technological University, Russia, Tatarstan, Kazan\nState Scientific Research Institute of Medical Polymers, Russia, Moscow\nScientific Research Institute of Chemistry and Technology of Organo-Element Compounds, Russia, Moscow

Collaborators

  • Westfälische Wilhelmas-Universität Münster / Anorganisch-Chemisches Institut, Germany, Münster\nSib Tech, Inc., USA, CT, Newington\nUniversity of Tokyo / Faculty of Pharmaceutical Sciences, Japan, Tokyo\nVirginia Commonwealth University / High Technology Materials Center, USA, VA, Richmond

Project summary

The objective of the present project is to develop the gas-permselective film membrane materials for public health and personal chemical dosimetry, on the basis of carbo-functional oligo-siloxanes.

Distinctive features of polyorganosiloxane block-copolymers on the basis of carbo-functional oligo-siloxanes are a high transparency, photo- and hydrolytic stability, thermo- and frost resistance, bioinertness, selective gas-permeability, high physical-mechanical and electric characteristics and also heightened resistance to influence of natural and induced radiation.

The realization of the present project supposes necessity of development of synthesis methods of organosiloxane block-copolymers (on the basis of carbo-functional oligo-siloxanes) and manufacturing technology of thin and asymmetrical (with a ultra thin piding diffusion layer) film gas-permselective materials and products from them, suitable for use in public health and applied ecology. These are oxygenators, ware for blood storage, biocompatible antiburn means, products for ophthalmology, transplanthology etc. for medicine practice and new personal chemical dosimeters (monitoring system “on a lapel” [1]) for applied ecology {for the task of on-site monitoring of such industrial toxicants as aromatic amines (N,N-dimethylaniline, N,N-diethylaniline) and hydrazine derivatives etc.} in workplace and environmental atmospheres and those associated with personal activities).

Besides with the help of new polyorgano-polysiloxane block-copolymers can be resolved a problem of localization of the centers of radiocontamination by means of their temporary “macrocapsulating”.

The present proposal corresponds to the aims of ISTC (contributing to conversion processes, in particular, support of the "weapon" scientists and engineers at fulfillment by them of applied researches and mining of know-how’s in the peace purposes in the field of new materials creation for environmental protection and health of the man).

The sharp necessity of development of new generation of membrane selective materials on the basis of polyorgano-polysiloxane block-copolymers is determined by that, for example, well-known “MEM-213” (USA, General Electric Corp.) does not allow to decide all complex of present technical problems in membrane technologies for medicine practice and applied ecology.

Possessing possibility of regulation of a composition and microheterogeneous structure of compounds on the basis of polyorgano-polysiloxane block-copolymers, the writers of the project will create materials with a complex of beforehand given properties, among which especially it is necessary to mark:

- High hydrolytic stability (in 4-5 times superior “МЕМ – 213” and “SILAR”) and heightened chemical resistance in acid and alkaline mediums;

- Heightened gas-permeability on oxygen and nitrogen (accordingly in 3,5-4,0 times as compared with “МЕМ – 213” and “SILAR”) without an essential decrease of gas-separation selectivity.

The results of the project will support further development of researches, spent earlier by the performers, with reference to technologies of new gas-permselective membrane materials creation – modified polyorgano-polysiloxane block-copolymers for public health and personal chemical dosimetry. In that context the project has not a precedent in the world.

The indicated objective of the project will be reached with the help of unified scientific – methodological collective of the highly professional researchers from four leading Russian organizations [M.V.Lomonosov State Academy of fine chemical technology (MIFCT), State Scientific Center “GosNII of Chemistry and Technology of elementoorganic compounds” (GNICHTEOC), State Scientific Research Institute of Medical polymers (IMP), Kazan State Technological University (KSTU)], having positive experience within the framework of scientific-technological cooperation with ISTC in adjacent areas of chemical-technological, analytical and medicinal problems (see, for example, CD-Library ISTC – PRA, Abstract #4090 “Analytical Technologies for On-Site Monitoring of Aromatic Amines and Hydrazines”) and owning by methods of new materials synthesis and processing and creation on their basis of special products of medical and ecological techniques (see also references [2-8]).

The expected results of the project and their scientific novelty consists in the fact, that methods of synthesis of new polyorgano-polysiloxane block-copolymers and materials on their basis adequate the purposes of the project for the first time will be designed. The polymers and films on their basis having high gas-diffusion permeability, stability to operating of toxic components of atmosphere, solvents, heat and irradiation will be obtained. The complex estimation of medicinal-biological effects of obtained film membranes use, and also screening of special gas-permeable membranes with selective properties ensuring active diffusion of vapours of technogene toxicants in personal chemical dosimeters will be made. The comparison gas-permeable membranes properties with properties of known materials will be conducted.

After realization of the considered project in a full volume its outcomes can and should be utilized at creation of hightechnological commercially significant production of new gas-separation film membranes for medicine practice and applied ecology.

For the solution of a proposed systemic task the realization of synthetic, medicinal-biological and analytical scale researches on following directions are planned:

· Improvement of obtaining methods of new organosiloxane materials;

· Mining of the conception of synthetic design (chemical “assembling”) with the purpose of combination of properties of “flexible” (siloxane) and “hard” (organic) blocks and its experimental approval;

· Forming of film and membranes with determined microstructure from solutions with use of phase-inversion method in a system polymer-solvent-nonsolvent;

· Implementation of laboratory and preclinical tests of film membranes with registration of biomedical effects of membrane separation;

· Screening of gas-diffusion membranes ensuring selective free diffusion of analyzed compounds to sorbent;

· Selection of the dosimeter ensuring diffusion inside of permeable barrier (membrane) pursuant to a gradient of concentration of analyzed matter;

· Screening of sorbent and reagents ensuring quantitative extraction (absorbtion) of admixture quantities of toxic matters from analyzed air environment;

· Study of conditions of a quantitative desorption of analyzed matters from the dosimeter for an estimation of temporal exposition by toxicants;

· Institution of quantitative intercommunications: “toxicant concentration (exposition time of the dosimeter) in air environment-the dosimeter response”;

Study of a possibility of visual detecting of a degree of an exposition by toxic compounds.

The outcomes of activity can present significant interest for foreign collaborators with one have agreed to cooperate with the participants of the project and are interested in rendering of the methodical recommendations in questions of an estimation of quality of received film membranes and possibility of their usage in public health and ecoanalytical chemistry.

In the present planned work the systemic (complex) approach at information support for risk analysis of the use of new generation of gas-permselective film membranes, at all stages of their functioning, for the first time will be utilized; i.e. in a chain: synthesis - researches of physical-chemical and operational properties - an estimation of medicinal-biological and ecoanalytical effects of usage of project objects.

The methodology of the project includes developed by the performers hightechnological methods of synthesis and physical-chemical methods of analysis of substances and products.

At the carrying out of project the higheffective scientific equipment presented to performers by ISTC Project # 498-97 (chromatographic systems “SHIMADSU” and HP-HPLC 1100 with DA-detection) will be used.

The quoted references:

1. Newman A.R. Personal Dosimeters: Analytical Chemistry on a Lapel. // Anal.Chem. 1991, v. 63, N 4, p. 237A.

2. Final Technical Report on ISTC Project #498-97. Monitoring of Originals Nitrogen. / Project Manager, Academician, Professor Pobedimsky D.G. / 1999, 40 p.

3. Kirilin A.D., Sheludykov V.D., Polyvanov A.N. Method of creating of 1,3-bis(trimethylsilyl)-1,1,3,3-tetramethyldisiloxane. // Pat. USSR N 1455630, 1989.

4. Ryzhova O.G., Ob’edkova N.N., Kopylov V.M., Polyvanov A.N. Comparative study of structure and properties of photopolymerazed Oligosiloxanes with reactive vinil, acrilate and epoxy groups. // XI-th International Symposium on Organo-Silicon Chemistry, Sept. 1-6, 1996, Abstr. Montpeller II, France, p. 54.

5. Khananashvili L.M., Kopylov V.M., Murachvili D.U., Sokol’skay I.B., Tsomaya N.I., Shkolnik M.I., Iskhakova M.K. Carbo-Functional Oligoorganosiloxanes – Modifiers for Polymeric Materials. // Russian Polymer News. 1998, v. 3, N 1, pp. 7-11.

6. Raygorodsky I.M., Rabkin V.S., Kireev V.V. Polyorgano-polysiloxane copolymers. // Russian Journal – “Vysokomolekularny soedineniya”, seriya A, 1995, v. 37, N 3, pp. 445-469.

7. Korygorodsky A.R., Kopylov V.M., Arinushkina O.V., Kutepov D.F. et al. Polysiloxaneurethane as Connecting matters for creating of gas-separation membranes. // Pat. USSR N 1650656, 1991.

8. Evgenyev M.I., Evgenyeva I.I., Garmonov S.Yu., Ismailova R.N., Pobedimsky D.G. DAD-HLPC determination of dimethylhydrazine. // Russian Journal “Zavodskaya Laboratoriya” (“Industrial Laboratory”), 2000, v. 66 (printed).


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