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Molecular and Genetic Peculiarities of Resistance to HIV Infection

#K-799


Molecular and Genetic Peculiarities of Resistance to HIV Infection

Tech Area / Field

  • BIO-MIB/Microbiology/Biotechnology
  • BIO-CGM/Cytology, Genetics and Molecular Biology/Biotechnology
  • MED-DIS/Disease Surveillance/Medicine

Status
3 Approved without Funding

Registration date
12.09.2001

Leading Institute
Republic Center for Prevention and Avoidance of AIDS Infection, Kazakstan, Almaty

Supporting institutes

  • Kazakh Scientific Center for Quarantine and Zoonotic Diseases, Kazakstan, Almaty

Project summary

The present research is aimed at identifying those peculiar properties of the structural organization of genes which ensure resistance to the human immunodeficiency virus. It has been established recently that there are genetically conditioned differences in inpidual sensitivity to the human immunodeficiency virus. It was shown that certain receptors of chemokinins are receptors for HIV. At the same time, CСR-5 is the main co-receptor for macrophagotropic cells. Mutation of the CСR-5 gene responsible for the synthesis of chemokinin receptor of macrophages determines resistance of a person to HIV infection. Previously, the authors had accumulated facts on the incidence and people’s sensitivity to HIV infection. However, the resistance level has not been studied completely. That is why the AIDS Center will be dealing with identifying inpidual sections of genes responsible for resistance to HIV infection, and determining alleles and their frequency distribution within certain groups of people.
Besides, knowledge about geographic incidence of HIV subtypes is of great importance both for characterizing epidemics in this or that region and for concrete epidemiological researches.
The institutes involved in the project have qualified staff and experiment base for molecular and genetic researches.
Up-to-date techniques of molecular biology and medical genetics will be applied in the work.
As a result of the project, new techniques to diagnose and prevent HIV infection will be developed which reveal genome polymorphism in order to study molecular mechanisms to develop resistance to HIV infection within various population strata.
The scientists participating in the project, who had been previously connected with development of bacteriological weapons, will now be involved in dealing with other problems of preventing spread of HIV infection.
Foreign collaborators can take part in discussing the work results and annual plans. Also, we expect from them assistance in terms of methods in this research, information exchange in the course of progect implementation,provide comments to the technical reports.We are waiting the methodical help in this research. Shared use of certain equipment and test and sample materials. Cross-checks of results obtained in the course of project implementation. Conduction of joint seminars and workshop.


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