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Foot and Mouth Disease in Kyrgyz Republic

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Enhancement of the Foot and Mouth Disease Control Program in Kyrgyz Republic: Advancement in Diagnostic Assays and Control Measures

Tech Area / Field

  • AGR-VTH/Vaccines and Theraupetics/Agriculture
  • BIO-MIB/Microbiology/Biotechnology
  • AGR-DIS/Disease Surveillance/Agriculture
  • BIO-CGM/Cytology, Genetics and Molecular Biology/Biotechnology

Status
3 Approved without Funding

Registration date
10.12.2004

Leading Institute
Kyrgyz Research Institute of Livestock, Veterinary and Pastures, Kyrgyzstan, Bishkek

Supporting institutes

  • Ministry of Agriculture / Close Joint Stock Company Altyn-Tamyr, Kyrgyzstan, Bishkek

Collaborators

  • United States Department of Agriculture / Plum Island Animal Disease Center, USA, NY, Greenport\nThe University of Georgia / College of Veterinary Medicine, USA, GA, Athens\nColorado State University / College of Veterinary Medicine and Biomedical Sciences, USA, CO, Fort Collins\nIowa State University / Institute for International Cooperation in Animal Biologics, USA, IA, Ames

Project summary

The goal of the Project is to increase the efficiency of FMD control measures in the conditions of distant pasture cattle rearing, to establish modern diagnostic laboratory and to develop effective means of specific prophylaxis to provide stable epizootic freedom of livestock rearing.

Urgency: Foot-and-Mouth disease (FMD) affects cattle, sheep, goats, pigs and wild ruminants, causing significant production losses in adult animals and death in young stock. It is on the list A of the Office International des Epizooties (OIE), and is the single most important constraint to international trade in live animals and animal products.

The disease is spreading because of absence of modern diagnostic laboratory equipped with PCR and ELISA, and intra-republican inter-regional veterinary posts, animals’ insufficient immune background or its absence because of the reduction (partially carrying out) of animals preventive vaccination against FMD.

The tendency to global distribution, high contagiousness of the disease, broad spectrum of susceptible animals, a large number of immunological types and subtypes of the causative agent, variety of ways of secretion and distribution, the ability to be preserved for a long time both in external environment and in organisms of immune animals – all this causes a number of complex veterinary-sanitarian and economic problems. Rigid quarantine measures of FMD eradication disturb economic activities of agricultural enterprises; affect public, economic and interstate business relations. FMD epizootic doesn’t have geographical and climatic boundaries and can be spread in very short time to huge territories.

In connection with the above mentioned right and well-timed diagnosis is of paramount importance in FMD control. Unfortunately in Kyrgyz Republic there is no modern veterinary laboratory to meet the requirements of international organizations. That’s why one of the main tasks of the Project is to establish a diagnostic laboratory with modern equipment which will help to organize properly veterinary-sanitarian and specific prophylaxis measures against FMD to prevent economical damage caused by FMD epizooty.

In Kyrgyzstan FMD control is implemented by veterinary-sanitarian measures with obligatory systematic vaccination of small and horned cattle. However the problem of complex specific FMD prophylaxis in Kyrgyz Republic is at the stage of scientific development.

In connection with the above mentioned the Project is:


a) to establish a diagnostic laboratory with modern equipment to diagnosis the virus on time and rightly organize prophylaxis measures against FMD;
b) to isolate FMD virus from pathological material, to study its immunobiological properties and use for producing vaccine and to compare it with other FMD viruses to reveal the differences which can explain its attenuation.

Serological, virological and immunological investigations will be carried out to reveal the epizootic situation and immune background. The virus isolated during FMD outbreak will be studied and typified. The next task after identifying and investigating the immunobiological properties of the isolated virus is to produce experimental samples of the vaccine against FMD of small and horned cattle.

On the results of this investigation a new vaccine from the local strain against farm animals FMD will be proposed that will contribute to the creation of FMD epizootic freedom and help to prevent the economical damage caused by FMD.

Expected Results and Their Application.

Free-form description of expected results.


1. Establishing a diagnostic laboratory meeting the requirements of O.I.E. which will make it possible to diagnose FMD on time and develop the plan of measures against epizooty.
2. Analysis of the statistical data of veterinary reports for the last 30 years and revealing the objective laws of FMD manifestation and peculiarities of FMD epizooty.
As a result the most FMD unfree regions will be determined and accordingly the schemes of sanitation and prophylaxis will be developed.
3. Virus isolation and identification.
After typification the virus will be passaged in young rabbits. The antigenic activity of the discharged FMD virus isolates will be determined in young rabbits and their immunobiological properties will be investigated in different serological reactions.
4. Complete nucleotide sequence of isolated FMD virus.
The isolate will be passaged to show any reversion to virulence. The isolate will be passaged to show any reversion and virulence. The serial passaging of the virus will be sequenced and compared with the parent virus. The changes that may be associated with the changes in virulence will be compared with differences identified earlier. This will provide additional data about the genomic sequence responsible for virulence, help to coordinate and effectively conduct prophylaxis measures against FMD.
5. A lapinized vaccine from the local strain against cattle FMD will be approved and recommended to the veterinary practice. Optimum doses of two inactivated vaccine samples will be approved and recommended because the veterinary service of the Republic is extremely in need of such a biological preparation.

On the results of the data obtained normative and technical documentation on lapinized vaccine producing and application will be compiled.


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