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Heavy Metals Effect on Animal Cells

#2418


Studies of the Superheavy-metal Effect as a Stress-factor on Protein Biosynthesis and Cytoskeleton Integrity in Animal Cells

Tech Area / Field

  • AGR-OTH/Other/Agriculture
  • AGR-DIS/Disease Surveillance/Agriculture

Status
3 Approved without Funding

Registration date
18.02.2002

Leading Institute
Institute of Protein Research, Russia, Moscow reg., Puschino

Supporting institutes

  • Cancer Research Center, Russia, Moscow\nInstitute of Basic Biological Problems, Russia, Moscow reg., Puschino\nVNIIEF, Russia, N. Novgorod reg., Sarov

Collaborators

  • Institute of Structural Biology / Molecular Biophysics Laboratory, France, Grenoble

Project summary

The goal of the project is to study the influence of some heavy metals (Uranium 238, tungsten, tantalum and osmium) as stress-factors on the state of the protein-synthesizing system and on the integrity of cytoskeletal structures both in normal and tumour cells.

The following work is planned to be done within the scope of the project.

– develop methods of determining for each of the studied metals the type of a chemical compound, the mode of action and quantitative characteristics influencing significantly the living processes and cell fission;


– work out techniques for immuno fluorescent microscopy studies of the cells after heavy-metal action that would allow tracing the state of cell cytoskeletons;
– work out techniques for electron microscopy studies of ultrathin sections of the cells after heavy-metal action;
– test the capability of newly obtained phytohormones to protect animal cells from the heavy-metal action;
– work out techniques for studies of the morphology and intracellular distribution of ribosomes and possible changes in their structure after heavy-metal action; conduct a comparative study of the influence of heavy-metal action on normal and tumour cells.


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