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Revealing Individuals with High Radiation Sensitivity

#1373


Revealing the Hyperradiosensitive Individuals with the Aim to Reduce the Radiation Risk for Population in Areas with an Elevated Radiation Background

Tech Area / Field

  • BIO-RAD/Radiobiology/Biotechnology
  • ENV-MRA/Modelling and Risk Assessment/Environment

Status
3 Approved without Funding

Registration date
07.10.1998

Leading Institute
Research Testing Center for Radiation Safety of Space Objects, Russia, Moscow

Collaborators

  • Armed Forces Radiobiology Research Institute, USA, MD, Bethesda\nUniversity of Tennessee / College of Arts and Sciences, USA, TN, Knoxville

Project summary

The Project is a basic research in the field of environmental protection. Its implementation will results in developing and justifying the method which enables one, using the comparative analysis of blood samples, to reveal the group of radiation risk (hyperradiosensitive inpiduals) among population residing in contaminated areas. According to preliminary estimates, the percentage of such inpiduals ranges from 5% to 12%. It is these persons who, due to theirs raised sensitivity to radiation, are in need of intent dispensary supervision and of priority for them when applying preventive and protective measures in contaminated areas.

Finding the criteria for singling out hyperradiosensitive inpiduals will be conducted by making use of the mathematical models of hematopoiesis, which is a critical system in mammals exposed to low dose rate chronic radiation, as well as in the framework of the inpidual-based stochastic model describing the dynamics of radiation-induced mortality in nonhomogeneous (in radiosensitivity) mammalian population. In the latter model the radiobiological effects are considered on three levels: the critical body system (hematopoiesis), an inpidual, and a mammalian population including inpiduals with different radiosensitivity.

In these studies the advanced methods of constructing and investigating the mathematical models will be applied. In particular, the dynamical models of hematopoiesis will be investigated by making use of the qualitative theory of differential equations, the oscillation theory, and computer calculations. The stochastic model will be investigated by computer, too. Justification of the method of revealing hyperradiosensitive inpiduals will be implemented by making use of the published experimental and clinical data concerning the variability of radiosensitivity of mammals which manifests itself both at the level of population and at the level of hematopoiesis system and constituent cells, the data being generalized and analyzed in the framework of the project. The problems, to be resolved in the project, have not been studied in such a complex approach both in this country and abroad.

The project investigations are important for the fundamental science because they develop system and quantitative approaches in radiation biology and ecology. They will also be a substantial contribution into the search for new methods of the radiation risk assessment with allowance for the inpidual variability of radiosensitivity. Besides, the investigation will provide a new knowledge concerning the effects of low level chronic irradiation on mammals. Without doubts, this field of studies is of special theoretical significance.

The project results will be a matter of interest to practical use. The method proposed for revealing the radiation risk group enables one to carry out, efficiently and purposefully, the preventive measures among the population residing in contaminated areas and hence to reduce the risk for hyperradiosensitive inpiduals revealed as well as for population as a whole with substantial saving the resources. This method can also be applied for singling out the radiation risk group among persons subjected to occupational irradiation. Thus, the project is of substantial interest for scientific institutions and governmental organizations that deal with the problems of the environmental protection and the radiation safety.

The Project team includes specialists of high competence and expertise in the field of radiation risk assessment and radiation safety, in the field of mathematical modelling of radiation effects influence on vital body systems, as well as in the field of medical aspects of radiation effects on organism [1-6]. In particular, the project team involves 3 specialists with the title "Doctor of Science in Physics and Mathematics", 1 specialist with the title "Doctor of Medical Sciences", and, two members of the team being Professors. The project team involves 3 staff members of NIIIT (Pulse Technique), which are specialists in the radiation physics.

It is to be noted that the Project meets goals and objectives of the ISTC. Implementation of the Project will enable weapon scientists to redirect their experience to peaceful activity. In the framework of the Project they will be integrated into the international scientific community due to the interchange of information with abroad collaborators. In addition, the realization of the Project will support basic research for peaceful purposes, namely in the field of environmental protection.

Recent publications of the project participants:


1. Kovalev E.E., Smirnova O.A. Estimation of radiation risk based on the concept of inpidual variability of radiosensitivity. AFRRI Contract Report 96-1. Bethesda, Maryland, USA: Armed Forces Radiobiology Research Institute, 1996, 203 p.
2. Smirnova O.A. Mathematical model for assessment of radiation risk on long space mission. Advances in Space Research, 2002, v. 30, No 4, p. 1005-1010.
3. Smirnova O.A. Mathematical modeling of mortality dynamics of mammalian population exposed to radiation. Mathematical Biosciences, 2000, v. 167, p. 19-30.
4. Kovalev E.E., Smirnova O.A. Life-span of irradiated mammals. Mathematical modeling. Acta Astronautica, 1994, V. 32, P. 649-652.
5. Zukhbaya T.M., Smirnova O.A. An experimental and mathematical analysis of lymphopoiesis dynamics under continuous irradiation. Health Physics, 1991, V. 61, P. 87-95.
6. Darenskaya N.G., Korotkevich A.O. Nonspecific reactivity of organism and principles of forming of inpidual radioresistance. Moscow: Voentehinizdat, 2001 (Russian).


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