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Accelerator-Based X-Ray Medicine Device (R)

#0326


Development of the Technical Project of the X-ray Irradiator on the Basis of the Miniature Pulsed Accelerator ARSA for Application in Medicine.

Tech Area / Field

  • BIO-RAD/Radiobiology/Biotechnology
  • MED-DID/Diagnostics & Devices/Medicine

Status
8 Project completed

Registration date
05.01.1995

Completion date
26.11.1999

Senior Project Manager
Kondratenkov Yu B

Leading Institute
VNIIEF, Russia, N. Novgorod reg., Sarov

Collaborators

  • Lawrence Berkeley National Laboratory, USA, CA, Berkeley\nEURATOM-Ciemat, Spain, Madrid

Project summary

In Russian Federal Nuclear Center the miniature pulsed accelerator ARSA has been designed. This is the accelerator of electrons with direct action with 10-cascade Marx generator on voltage 1 MV with an oil insulation. It was used in the developments, connected with nuclear weapons control and testing.

Project aim - on the base of the pulsed accelerator ARSA to develop an x-ray (electron) irradiator for application in medicine to study possibilities of its application in other fields of science and technology.

It will differ from the existing nowadays x-ray sources by:

- high dose power (up to 3*108Сy/s in air);

- hard radiation spectrum (max. energy—1 MeV);

- minimal dimensions and weight (Ж 22Ox600 mm, 5O kg);

- high radiation parameters stability;

- ecological safety.

The x-ray irradiator can be applied for irradiation of donor blood and us components, being used for treatment of patients in the Center of Bone Marrow Transplantation, as well as for treatment of patients with congenital and acquired immunodeficiency syndrome (AIDS), newborn hemolitic desease, leulcemia, other oncologic and haematologic deseases.

Usually blood and its components are irradiated on facilities with isotope sources. The drawback to the facility GAMMACBLL-1000 with an isotope Cs-137 is that it is ecologically dangerous and that in principle the possibility of radiation accident exists. Activity of the isotopic source is very high (from 600 Ci to 2400 Ci depending on modification). GAMMACELL-10GO reguires a special room, trained staff and regular monitoring of radionuclide contamination. The burial of the waste used may be a problem. This facility is bulky nontransportable and expensive (about 70000 US $), With such facilities 12% of hematologic clinics of the US are equipped. [Blood. Vol.77 № 10 (May 15) 1991; pp.2096-2102].

The irradiator on the base of the accelerator ARSA, equipped with a compact biological shielding is an ecologically safe more convenient and low-cost (-25000 US $) alternative irradiator. The abvantage of the facility is that X-ray radiation occurs only at the instant when the facility is connected in a circuit. It maybe switched on and off by means of a remote-acting control panel under a specifical program.

In the mode of electron radiation the irradiator can be used for surface sterilization of products for medical purposes, for example, microsurgery and stomatology instruments, small artificial organs, suture material and so on. The sterilization dose is achieved near the tube window within 1 pulse.


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