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Radiation synthesis method for anti-tuberculosis medical preparation

#3096


Development of Radiation Synthesis Method for new Highly Efficient Antituberculosis Medical Preparation "Izodex"

Tech Area / Field

  • MED-DRG/Drug Discovery/Medicine
  • PHY-OTH/Other/Physics
  • PHY-PFA/Particles, Fields and Accelerator Physics/Physics

Status
3 Approved without Funding

Registration date
12.08.2004

Leading Institute
Budker Institute of Nuclear Physics, Russia, Novosibirsk reg., Akademgorodok

Supporting institutes

  • Scientific Center of Clinical and Experimental Medicine, Russia, Novosibirsk reg., Novosibirsk\nA.I. Burnazyan Federal Medical and Biophysical Center, Russia, Moscow\nSiberian Center for Pharmacology and Biotechnology, Russia, Novosibirsk reg., Novosibirsk\nSiberian Branch of RAS / Institute of Cytology and Genetics, Russia, Novosibirsk reg., Novosibirsk

Collaborators

  • US Department of State / FSU Bio Industry Initiative, USA, DC, Washington

Project summary

In present days the interest to the radiation synthesis of medical preparations through the activation of biopolymers is increasing. This method permits to conjugate the biopolymers with the active agents possessing the curing effect which in many cases becomes higher, and the toxic influence – lower. And up till now there is no highly efficient anti-tuberculosis preparation possessing high anti-tuberculosis activity in conjunction with the low toxicity and capable to sufficiently reduce the curing period for tuberculosis. The existing preparations can be used only in complex treatment together with other preparations, and the duration of treatment is rather high – 6 and more months. All existing preparations are very toxic and cause the destructive effects on liver and other body organs. The main reason of low efficiency of anti-tuberculosis drugs is stipulated by the fact that the tuberculosis micobacteria after entering into the human body occur inside the macrophages (cells of the immunity system), but unlike other bacteria that are quickly destroyed inside macrophages the tuberculosis micobacteria possess the ability to persist inside macrophages for a long time. Remaining in macrophages hardly accessible for the antibiotics the micobacteria have all necessary conditions for changing and acquiring the high resistance up to formation of L-forms.

The result of the common work of the Institute of Cytology and Genetics, Budker Institute of Nuclear Physics and Scientific Center for Clinical and Experimental Medicine is the development of laboratory technology for production of new anti-tuberculosis drug “Izodex” using the method of electron beam activation of the biopolymers (dextranes) which are conjugated with the isoniasidum possessing high anti-tuberculosis activity thus forming the complex penetrating into macrophages. The preliminary data acquired in animals tests permits to hope that “Izodex” will permit to reduce the treatment time of tuberculosis in 2-3 times.

The purpose of this project is the development of new highly efficient anti-tuberculosis preparation “Izodex”.


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