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Ultraviolet radiation influence on the human reproductive system

#G-2063


Comprehensive analyze of ultraviolet radiation influence on the human reproductive system

Tech Area / Field

  • BIO-RAD/Radiobiology/Biotechnology
  • MED-DIS/Disease Surveillance/Medicine
  • PHY-OTH/Other/Physics

Status
3 Approved without Funding

Registration date
26.02.2013

Leading Institute
Georgian Technical University, Georgia, Tbilisi

Collaborators

  • University of Tokyo, Japan, Tokyo\nEuro Mediterranean Academy of Arts and Sciences, Greece, Athens

Project summary

The objective of this project is to perform research and development work to study the adverse effects of UV radiation on the reproduction system of the human body.
The most sensitive to UV-function is cell - pision. The dose of 10-19 Jm-2 stops the pision of about 90% of the bacterial cells. But the growth and vitality of cells does not stop. Over time the pision is restored and causes the death of 90% of cells, suppression of the synthesis of nucleic acids and proteins, the formation of mutations necessary to bring the radiation dose to 10-18Jm-2.
Upon irradiation with light of a specific wavelength, electrical charge of the molecules decrees, they clump together and loose their activity - enzyme, hormone, antigen, etc. Photolysis and denaturation of proteins are parallel and independent from each other. They are caused by different ranges of radiation beams, photolysis is mainly caused by 280 - 302 nm and denaturation mostly by 250 - 265 nm length waves. The combinations of these processes determine the pattern of the cell under ultraviolet rays.
Ultraviolet rays trigger changes in nucleic acids, which affect the growth, pision, heredity, cells, i.e., on the main manifestations of life. The value of the mechanism of action for nucleic acid is due to the fact that each molecule of DNA (deoxyribonucleic acid) is unique. DNA - inherits memory cells. In its structure it encrypts information on the structure and properties of all cellular proteins. If the protein is present in every living cell in the form of hundreds of identical molecules, DNA stores information about the structure of the cell as a whole, the nature and direction of the metabolic processes in it. Therefore, disturbances in the structure of DNA can be irreversible and cause serious disruption of life.
In order to be able to predict the process of action of ultraviolet rays, we have to find out in what context does the energy of the molecules interact with the energy of the fragments and chemical compounds with ionization energy.
The scope of the work is represented by four tasks. Each task – the development of the physical model of UV radiation influence on human reproductive system; development an assessment of propagation mechanism of UV rays and the effect on the parameters of the human reproductive system; identification of effective methods for studies of the effect of UV on the reproductive system, and execution of the complete set of elaboration of training modules for doctors, nurses and patients aimed to know well the negative influence of UV radiation and approaches for their proper use – comprises the characteristic milestones of the research and development work.
The following should be regarded as major expected final results:
Assessment of propagation mechanism of UV rays and the effect on the parameters of the human reproductive system.
Definitions of the characteristic parameters of the reproductive system and assessment of adverse events.
Identifying effective methods for studies of the effect of UV on the reproductive system.
Taking into account the factor of solar activity that conducts to UV radiation, this will help in implementing the prevention of radioactive contamination of people.
Training the doctors for proper use devices with UV radiation in the treatment of patients, and patients who received UV irradiation, for their treatment and pregnancy planning.
The work on the project will be performed by the GTU team supporting with group of biomed researchers, medical doctors and clinical personal from Tbilisi State University Medical Clinic. Leading scientific workers having an experience with technology development investigations belong to the Institute. They represent the main body of the project team. Ten of them have scientific ranks. Six researchers of previous weapon expertise participate in the project. The proposed project provides an opportunity for continuing our ability to be reoriented to peaceful activities. The project supports as well earlier applied peaceful investigations helping human health care. The integration of the scientists of the GTU into the International Science Community is encouraged. The project sustains the actual prospects of setting up a joint venture with foreign establishments, thereby transmitting to the market economy.
It is intended to choose foreign collaborators at the time of considering the project. Their interest will provide the opportunity for exchanging information during implementation of the project, commenting the technical reports, using joint equipment and materials under production, checking the results and the technical control of the project activities, joint attendance to conferences, workshops and participation in publications.
The technical approach and methodology have been preconditioned by the objective of the project, its scope and expected final results.
The equipment and facilities used earlier to conduct the research and development work for optical and biological investigations are mostly available at the GTU.


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