Decorporators of Radionuclides
Development of Chelating Agents from Natural Sources for the Decorporation of Radionuclides
Tech Area / Field
3 Approved without Funding
Georgian Technical University, Georgia, Tbilisi
- Scientific-Research Center for Radiobiology and Radiation Ecology, Georgia, Tbilisi\nCenter for Coordination and Implementation of Scientific, Technological and Socio-Economic Projects, Georgia, Tbilisi
- University of Oxford / Churchill Hospital, UK, Oxford
Project summaryContamination of humans by highly toxic radionuclides is a major concern for nuclear industry and health organizations. The threat of contamination concerns both radiation workers and general public. Both groups can acquire significant body content of toxic radionuclides as a consequence of direct exposure to radionuclides during radiation accidents, or as a consequence of radioecological changes caused by major accidents. There is a need to develop effective methods of treating people contaminated with radionuclides. Decorporation of radionuclides from the body by increasing the speed of extraction of these substances is the most important and effective method of treatment. This will reduce the dose of radiation delivered to the most sensitive cells of the body and consequently reduce radiation damage. Decorporation of radionuclides is usually achieved by using chelating agents. A large number of chelating agents have been developed during the last decades but all with a limited effect. The available chelating agents are very slow in acting and even not effective if applied later than a few days after the contamination. Therefore, there is a great need for the development of new chelating agents. A potential source of such agents is natural substances found traditionally. The applicants have extensive experience in Traditional Medicine of Georgia and are currently applying modern scientific methods to evaluate the rational use of natural substances in the Traditional Medicine of Georgia.
Continued use of nuclear both for material in military and for non-military purposes inevitably carries the risk of public exposure to radionuclides. While a limited success has been achieved by the application of natural or synthetic agents there still is a great need for such substances to be developed. Our project will be carried-out with a logo: “Pourqoi pas”? (why not?) and will aim to develop suitable agents for the decorporation of radionuclides from softer harmless natural sources.
Method applied for this project is based on centuries-old traditional medicine. Although decorporation of radionuclides is a recent problem and our ancestors had no need for tackling problems of decorporation of radionuclides, still effective methods of cleansing of the body and elimination of toxins constitute a major component of the traditional medicine. Therefore, application of traditional medicine can be beneficial in this respect.
The participants of the project have been involved in Traditional Medicine of Georgia and compared it with traditional medicines of other countries such as China, Mongolia, Tibet, India, Pakistan and other countries. These traditions have been refreshed by the application of modern research methods and laboratories in recent studies.
The work conducted by the leading organization of the proposed project includes the evaluation of the traditional medicine of Georgia against modern standards of ecological purity, effectiveness and "soft action", with emphasis on preventive measures and safety.
The leading organization has already created treatment-and-preventive facilities against atherosclerosis, antispasmodic, germicidal, against menopause, neurosis’s retrieving metabolism, against disease of a thyroid gland, traumatology etc.
In proposed project Extensive experience and knowledge of the leading investigator shall be utilized.
The aim of the project is to develop effective methods of the decorporation of radionuclides from the body with the help of cleansers. Special attention will be given to natural ingredients.
In order to decorporate radionuclides, a direct interference with the physiological and biological processes will be used. There will be special means developed for faster decorporation of radionuclides from its primary depots, as well as for already absorbed radionuclides.
Processing and development of treatment and re-habilitating methods will vary, depending on the way of how radionuclides were incorporated into the human body and what kind of injury they caused: e.g. if the body is contaminated through lungs by breathing a contaminated air, or through the gastro-intestinal channel with food and water, or through wounds and scratches on skin, through burned surface of the skin, or through intacted skin. We have already obtained some preliminary results.
Special attention will be paid to preventive and special which will help to regulate metabolism, neutralize and eliminate toxic elements from the body, stimulate immune system and thus prevent development of the illness.
The optimal types of vegetative sources and natural substances will be selected so gathering of ecologically clean materials will be organized. Resources will be studied chemically, radiologically, etc. Dose optimization will be tested in laboratory animals such as rats, mice and rabbits.
This will be achieved by administration of radionuclides through different routes and clearance tests.