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Phage Preparation to Control Poultry Infections

#G-1807


Developing an Ecologically-Safe, Polyvalent Phage Preparation Effective in Preventing and Treating Clostridiosis and Staphylococcosis in Poultry

Tech Area / Field

  • BIO-OTH/Other/Biotechnology
  • BIO-MIB/Microbiology/Biotechnology

Status
3 Approved without Funding

Registration date
23.11.2009

Leading Institute
LEPL Agrarian Radiology and Ecology Institute, Georgia, Tbilisi

Collaborators

  • Universite de Paris-Sud / Institut de Génétique et Microbiologie, France, Orsay\nUniversity of Florida / Emerging Pathogens Institute, USA, FL, Gainesville\nIntralytix, Inc., USA, MD, Baltimore

Project summary

At the background of the worsened ecological situation worldwide, clostridial and staphylococcal infections pose a grave danger to both the poultry and animal farming and human health. The clostridioses are present in Georgia too. Incidence of isolation of their infectious agents from the soil and from the environmental objects amounts 35% and 19%, respectively.

In treatment of the poultry clostridioses and staphylococcoses the chemical preparations (antibioticsa and sulfanilamides) are used, after which the birds often remain bacterial carriers; the latter sometimes becomes a basis for complicated epidemiological situations. The same etiological factors are cause of heavy diseases in humans, occasionally with lethal outcome. Maintaining healthy poultry and resulting safe products will be an essential support for the healthcare system.

Currently, when the states of European Union (2006) and the USA (2009) prohibited usage of major antibiotics in the poultry and animal farming, a suggestion was made that sharp decrease of antibiotics might exert a negative impact on the food safety, on treatment of sick poultry, unless some alternatives for the antibiotics would not be found.

Some proposals in this direction have been made already although the specific bacteriophages should be considered as the most effective alternative, which has both preventive and treatment properties. Investigation of the bacteriophages revealed their advantage over the antibiotics. Specifically, production of the resistant strains against phages is impossible, phages can enter into the focus of microbial concentration and reproduce on expense of a bacterium, up to its total lysis, etc.

The Goal of the Project is isolation and investigation of the poultry clostridioses and staphylococcus inducing agents in Georgia and of the homologous virulent bacteriophages against above agents. Following selection of the bacteriophages obtained, on their basis the polyvalent phage preparation will be elaborated and produced, a curative-prophylactic effectiveness of which will be evaluated in production experiment.

The main result of implementation of the produced and studied polyvalent bacteriophages implies that with their aid a safe, ecologically healthy poultry products of high quality will be supplied to the human population.

Following a due registering of the polyvalent phage preparation, an interested commercial organization will be able to produce the aforementioned preparation in order to make it affordable for the poultry productions and commercial firms.

Successful fulfillment of the Project is guaranteed by the implementers – “weapons scientists” (Professors and Doctors: M.Oniani, T.Lobzhanidze, M.Natidze, S.Rigvava, J.Nachkebia, Ts.Sikharulidze, and M. Kereselidze) and other scientists (Kh.Khutashvili, Kh.Bujiashvili, G.Okujava, T.Zhorzholiani), who, by their scientific activities, have shown high competence and ability for coping with the most complex scientific problems.

In fulfillment of the Project a scientific and organizational aid will be provided by American scientists, which have an ample experience in the present domain. Up-to-date bacteriological, biochemical, serologic, and other research methods will be used in the Project implementation.

The clostridial and staphylococcal polyvalent phage preparations are viewed as an alternative for the antibiotic and other chemical antimicrobial means and as a basis for obtaining safe poultry products.


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