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New Vaccine against Foot-and-Mouth Disease

#KR-918


Biotechnological Methods of Farm Animals Protection against Foot-and-Mouth Disease

Tech Area / Field

  • AGR-VTH/Vaccines and Theraupetics/Agriculture
  • BIO-MIB/Microbiology/Biotechnology
  • AGR-DIS/Disease Surveillance/Agriculture
  • BIO-CGM/Cytology, Genetics and Molecular Biology/Biotechnology

Status
8 Project completed

Registration date
02.09.2002

Completion date
30.05.2005

Senior Project Manager
Weaver L M

Leading Institute
Kyrgyz Research Institute of Livestock, Veterinary and Pastures, Kyrgyzstan, Bishkek

Collaborators

  • Iowa State University / Institute for International Cooperation in Animal Biologics, USA, IA, Ames\nUniversity of Georgia / Department of Pathology, USA, GA, Athens

Project summary

The goal of the Project is to increase the efficiency of FMD control measures in the conditions of distant pasture cattle rearing and develop effective specific prophylactic measures for stable epizootic freedom of livestock rearing.

Foot-and-Mouth Disease (FMD) is a highly contagious viral disease of cattle, sheep, goats and pigs and species of wild ungulates. It is an OIE List A, and is the single most important constraint to international trade in live animals and animal products.

All countries that are free of FMD maintain strict import controls, and many of those that have FMD have eradication programs in place, in order to achieve freedom, and gain access to the lucrative markets of North America, Japan and Europe for their animal exports.

Vaccines against FMD provide, at best, only temporary protection because there are seven antigenically distinct serotypes, and within each serotype there is a spectrum of antigenically variable strains, it is essential to match outbreak strains with vaccine strains. This inevitably delays the implementation of vaccination and frequently requires the development of new vaccine strains.

The problem of FMD is very acute in the Kyrgyz Republic, and new locations of the disease appear every year. According to the data of veterinary reports and our research for the last 10 years there were several FMD outbreaks among horned and small cattle. In the farms of the Republic the disease is accompanied by large losses of milk, meat and other kinds of animal production, makes commercial operations difficult and by that puts huge damage to animal industries and as a whole to national economy.

The world experience has allowed to work out three main FMD control measures:

– veterinary- sanitarian measures;


– the method of annihilation of the infected animals;
– vaccinoprophylaxis.

In Kyrgyzstan the FMD control is implemented by veterinary-sanitarian measures with obligatory systematic vaccination of horned and small cattle by Russian vaccine that is insufficient for full eradication of the infection. However the problem of FMD complex specific prophylaxis is at the stage of scientific development.

In this connection the main goals of the project are:

– study the FMD distribution in the Republic and the features of its epizootic process under the distant cattle rearing;


– sequestration and study FMD virus field isolates;
– comparing of sequestered isolate with standard FMD virus strains;
– production of vaccine preparation from the local isolate;
– study vaccine antigenic features on the laboratory and naturally susceptible animals;
– study vaccine immunogenic features;
– on the base of the obtained results development an optimal system of the FMD control prophylactic measures under the distant pasture cattle rearing.

For the first time in the conditions of Kyrgyz Republic virological research will be conducted on a large scale for sequestration and identification of horned cattle FMD field isolate, the experimental vaccine series will be produced, besides antigenic and immunogenic activity of the preparation will be studied in the experimental and field conditions.

Highly skilled specialists experienced in the field of virology will be involved in the Project: from the Kyrgyz National Academy of Sciences -virologist Academician Professor Khanduev T.T.; virologist Academician of the Russian Academy of Veterinary Sciences, Professor Nurgaziev R.Z. who studied and underwent a probational period at the virology laboratories of Russia and Germany; specialists of the Veterinary Department of the Kyrgyz Republic – virologist Dr. Chinaliev B.C.; from the Kyrgyz Agrarian University – Dr. Bularkiev K.U.; Dr. Birimkulova A.T.who underwent a year’s probational period at Giyssen University of Germany and others.

Expected Results.

As a result of the research the new vaccine from the local strain against FMD of farm animals will be obtained that will contribute to FMD epizootic freedom and help to prevent economical damage caused by FMD.

For the first time in the conditions of the Kyrgyz Republic virological research will be conducted on a large scale for sequestration and identification of horned cattle FMD field isolate, the experimental vaccine series will be produced, besides antigenic and immunogenic activity of the preparation will be studied in the experimental and field conditions.

The vaccine obtained will be recommended for FMD prophylaxis in animal farms.


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The International Science and Technology Center (ISTC) is an intergovernmental organization connecting scientists from Kazakhstan, Armenia, Tajikistan, Kyrgyzstan, and Georgia with their peers and research organizations in the EU, Japan, Republic of Korea, Norway and the United States.

 

ISTC facilitates international science projects and assists the global scientific and business community to source and engage with CIS and Georgian institutes that develop or possess an excellence of scientific know-how.

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