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Treatment for Rectal Cancer

#1525


New Approach to the Treatment for Advanced Primary and Recurrent Rectal Cancer Based on Cytoreductive Surgery and Controlled Flow-Through Intravenic Hyperthermic Chemotherapy

Tech Area / Field

  • MED-OTH/Other/Medicine

Status
8 Project completed

Registration date
21.05.1999

Completion date
20.06.2006

Senior Project Manager
Weaver L M

Leading Institute
State Research Institute of Organic Chemistry and Technology, Russia, Moscow

Supporting institutes

  • Ministry of Health / State Scientific Center of Coloproctology, Russia, Moscow\nCancer Research Center, Russia, Moscow\nMoscow State University / Department of Chemistry, Russia, Moscow

Collaborators

  • Washington Hospital Center / Washington Cancer Institute, USA, DC, Washington\nHospital of IVREA, Italy, Ivrea

Project summary

Project title: New approach to the treatment for advanced primary and recurrent rectal cancer based on cytoreductive surgery and controlled flow-through intrapelvic hyperthermic chemotherapy.

Project Goal

The aim of the project is to develop modified Heated Intraoperative Intraperitoneal Chemotherapy method applicable to treatment of locally advanced primary and recurrent rectal cancer together with cytoreductive surgery and new method of treatment for this type of cancer based on the same surgery and controlled flow-through intrapelvic hyperthermic chemotherapy and to compare the efficiency of these methods.

Expected Results and their Acceptance to ISTC Objectives

The implementation of the project will allow developing new method for locally advanced primary and recurrent rectal cancer treatment what will result in improving the long-term results of treatment in formerly incurable patients. The method will be introduced into practice Russia and USA. Moreover it will be possible to use this methods for more successful treatment for other forms and localization of cancer.

The obtained data will be published in the form of controlled prospective randomized investigation, analytical procedures and the developed methods will be described and practically demonstrated.

Following are potential roles of foreign collaborators:


· application of the developed methods in practice of treatment for rectal carcinomas as well as for other forms of cancer;
· comparative studies of new and existing methods of cancer treatment.

The expected results fully correspond to the objectives of ITSC goals.

Technical Approach and Methodology

In accomplishing the Project the following methods are to be developed:


· modified method of Heated Intraoperative Intrapelvic Chemotherapy (HIIC) applicable to treatment locally advanced primary and recurrent of rectal cancer together with cytoreductive surgery;
· methods for determination of chemotherapy agents (for example mytomicin C) in aqueous solution, human tissues and biological fluids based on chromatography/mass-spectrometry (High Performance Liquid Chromatography/Mass Spectrometry (HPLC/MS), Supercritical Fluid Chromatography/Mass Spectrometry (SFC/MS) and, respectively, Mass-spectro/Mass Spectrometry (MS/MS) and High Performance Thin Layer Chromatography (HPTLC);
· method of flow-through HIIC and respective hardware;
· method of registration for cancer cells content in aqueous solution and determination of their state;
· method for cleaning of biological tissues from cancer cells;
· method of cleaning of polymer materials used in HIIC from chemotherapy agent.

The proposed new method of HIIC will allow to determine chemotherapy agent distribution in used aqueous solution, body fluids and tissues and to compare efficiency of static and flow-through HIIC combined with cytoreductive surgery with conventional treatment of rectal cancer. Developed method of the cleaning of biological tissues from cancer cells and their elimination due to flow- through HIIC will allow (after cytoreductive surgery) to decrease the possibility of metastases formation improving long-term results of treatment for locally advanced rectal cancer.


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