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Disinfectants Against Anthrax Agent

#2970


Novel disinfectants for decontamination of the objects affected by anthrax agents in biological terror acts

Tech Area / Field

  • BIO-SFS/Biosafety and BioSecurity/Biotechnology
  • BIO-CHM/Biochemistry/Biotechnology
  • BIO-MIB/Microbiology/Biotechnology
  • CHE-IND/Industrial Chemistry and Chemical Process Engineering/Chemistry

Status
8 Project completed

Registration date
29.12.2003

Completion date
30.10.2006

Senior Project Manager
Frenkel B M

Leading Institute
Research Center of Toxicology and Hygienic Regulation of Biopreparations, Russia, Moscow reg., Serpukhov

Supporting institutes

  • All-Russian Research Veterinarian Institute, Russia, Tatarstan, Kazan

Collaborators

  • US Environmental Protection Agency, USA, DC, Washington\nDepartment of the Army / Army Reseash Office, USA, NC, Durham

Project summary

At present, there exist disinfecting means and methods developed and approved by the Russian Ministry of Health that are being used for work with microorganisms of pathogenicity groups 1 and 2, as well as the procedures for disinfecting different objects contaminated by such microorganisms. However, the indicated means and methods were developed to be used in the laboratories and hospitals and do not take into account the present-day requirements.

Recently, the ARVI in cooperation with other research institutes has conducted the search of novel preparations related to different classes of chemical compounds (quarter connections of ammonium, aldehydes and aldehyde-based compounds, electro-activated salines and their mixtures), that have bactericidal, sporicidal, virulicidal, and fungicidal features (Certificate #168077; AC #330651; AC #262178; AC #249670; AC #1432980; AC #1483887; AC #230689; AC #1467814; AC #321943; AC #262305; AC #240608; Russian patent #2158140).

The objective of the project is search and development of effective disinfecting means for decontamination and sanitation of the objects infected by the agents of especially dangerous infections, anthrax in particular, since the recent events lead to the conclusion that these microorganisms will be most likely used in the acts of bioterrorism.

It is suggested to develop novel formulations of disinfectants that meet the following requirements:


– possibility to use the industrially produced components for which the normative-and-technical documentation is available;
– using registered disinfectants on their basis;
– simple application methods;
– sporicidal action towards anthrax spores.

Long-term experience of the project authors in development and production of disinfectants (ARVI), as well as in toxicological studies (RCT&HRB) gives a hope that methodical and practical difficulties of the project will be successfully overcome.

The project will considerably contribute to resolving one of social problems of most concern - redirection of former “weapon” professionals’ creative potential. Basic and applied research in the framework of international scientific society in the field of disinfectology will allow lowering the “efficiency” of using microorganisms as a terror tool and enhancing safety of the work with pathogen microorganisms.

To achieve the goal, the following tasks will be fulfilled:


– select disinfectants having bactericidal and sporicidal features among the existing ones;
– develop novel disinfecting compounds;
– study sporicidal features of the chosen compounds;
– conduct toxicological studies of the most promising chosen compounds having sporicidal features;
– develop the procedures to use the chosen compounds.

Foreign collaborators could participate in the project as follows:


– patent-information support of the project;
– preparation and review of scientific publications;
– scientific seminars to discuss the key issues on the project.


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