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Device for prostate cancer early diagnosis

#G-2056


Near Infrared Irradiation Based Novel Medical Device for the Diagnosis of Early Stage of Prostate Cancer Development

Tech Area / Field

  • MED-DID/Diagnostics & Devices/Medicine

Status
3 Approved without Funding

Registration date
08.02.2013

Leading Institute
Georgian Technical University, Georgia, Tbilisi

Collaborators

  • Bonn University, Germany, Bonn\nUniversity of Washington / Department of Bioengineering, USA, WA, Seattle\nUniversity of Manchester / School of Chemical Engineering and Analytical Science, UK, Manchester

Project summary

Deaths from cancer worldwide will continue to rise, with an estimated 12 million deaths in 2030. Prostate cancer, after lung cancer, is the second cause of cancer death in men worldwide. Some advanced prostate cancers have well known symptoms. However non-cancerous diseases of the prostate, such as benign prostatic hyperplasia (BPH) cause same symptoms. On the other hand, at very early stages, prostate cancer has no symptoms, the tumor dimension is quite small and it is extremely difficult to detect it. At the later stages, treatment or surgery has very low efficiency. To find cancer in people who do not have symptoms of that disease is extremely important. If prostate cancer is detected at an early stage it can be successfully cured by different methods. Consequently, it is possible to save lives.
Different methods, such as measurement of the amount of prostate specific antigen in the blood, digital rectal examination, trans-rectal ultrasound diagnosis are used for prostate cancer diagnosis. Unfortunately these methods are not able to detect cancer at early stage of it’s development.
Magnetic resonance imaging and positron emission tomography made advances in prostate cancer diagnosis. However, these methods require extremely expensive and complicated technique and could not be used widely in clinics. Besides, high magnetic field and radiofrequency irradiation, X-rays, radioactive substances used in these methods also can post some risk. Unfortunately, there is no low cost and easy method so far which could give reliable diagnose of prostate cancer at early stages, when the dimensions of newly developed cancer tissue are of millimeter or sub-millimeter size.
In this project, we propose to create an advanced, simple, cost effective and reliable system for early diagnosis of prostate cancer. This system could be placed at any clinic for prostate cancer diagnosis. This system will not require special skills or experience from the personnel. The methodology is based on established fact that near infrared light may pass through biological tissues. Special software will be developed for analysis of prostate infra-red images. The diagnosis system would allow distinguishing differences between cancerous and noncancerous tissues and identify the location of the cancer. Charge-coupled device (CCD) camera connected to the computer will be used as infrared images detector.
It is difficult to overemphasize economic, social and other impact of our device - it will help to save lives.
Doctor of biological science Besarion B. Partsvania will be the Project manager. B. Partsvania is highly qualified scientist. His specialization is biophysics. He was manager-principal investigator in numerous scientific projects, particularly in projects awarded by ISTC, GNSF etc. During last two years Partsavnia participated in 9 international scientific forums. His total number of publications is 80. Publications of B. Partsvania together with G. Petriashvili and other team members concerns to the issue of proposed project are:
Possibility of Using Near Infrared Irradiation for Early Cancer Diagnosis, Electromagnetic Biology and Medicine in press. Modeling of early prostate cancer diagnosis by using of near infrared irradiation, published in proceedings of 7th international workshop on biological effect of electromagnetic fields, Malta 2012-http://www.um.edu.mt/events/emf2012- the same authors.
Team members Dr. Gia Petriashvili and Dr. Andro Chanishvili are high qualified scientists. Their sphere of interest includes Optics, Photo and Electro optics of Liquid Crystals, Polymer and Liquid Crystal doped nanoparticles. It is obvious that their knowledge and experience will promote project implementation. Full number of publications of G. Petriashvili is 120, Patents-3. Full number of publications of Dr. Chanishvili is 100. Dr. Petriashvili was PI and A. Chanishvili was a scientific investigator in the project related to the cancer diagnosis using liquid crystal lasers - Grant of GNSF, # ST07/6-222, Liquid Crystal Laser for Optical Devices of Cancer Early Diagnostics”.
Team member David Kochiashvili is physicians, surgeons. He Graduated from Georgian Medical University in 1981. In 1998 maintained doctoral degree. He is Head of urological affairs of the Academician Kipshidze central clinics of Georgian Medical University 2007-up to now. D. Kochiashvili is Member of expert commission of ministry of healthcare and ministry of justice of Georgia, member of European urologic association, Head of urologic association of Tbilisi. D. Kociasshvili is author of 73 scientific publications. He was Invited professor in Sweden (2001), Israel (2006).
Team member Alexandre Khuskivadze is physician, surgeon. He is head of the surgical department of the “GIDMEDI” joint Georgia- Israel clinic: from 2007-up to now. He is invited professor of the chair of urology of Georgian Medical University.
Dr. Tamaz Sulaberidze is specialists of imaging processing, digital data analyze and processing. He developed methods of prognosis and modeling of random events.
Levan Shosiashvili has good experience in image processing and developing of software for different scientific needs. Nino Ponjavidze is young perspective female scientist.
4 of team members are former weapon scientists. They together with others will work in civilian environment on civilian problem and will contribute to peaceful problem, thereby proposed project completely address ISTC objectives.
Scopes of activities include:
1.1. Patients‘ diagnosis, surgical operations, microscopic and cytological investigations of the prostate tissues.
12. Investigation of penetration of IR light in noncancerous prostate tissue in passed mode.
1.3. Investigation of IR light penetration into the noncancerous prostate tissue in back scattered mode.
1.4. Computer processing of the noncancerous prostate tissue images with the purpose of creation of the software.
1.5. Investigation of the optical properties of the noncancerous prostate tissue in the polarized IR light.
2.1. Investigation of the prostate cancerous tissue in the passed IR mode.
2.2. Computer processing of the cancerous prostate tissues IR images.
2.3. Investigation of prostate cancerous tissues in polarized IR light.
3. Creation of the working model of the prostate cancer early diagnosis.
Role of foreign collaborators are:
· Participation in the development of project proposal and work plan.
· Exchange of information during project implementation.
· Review of technical reports.
· Joint seminars, workshops, meetings, consultations.
· Sharing of scarce materials, samples, resources.
Efforts towards the potential commercialization of project results.


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