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Biological Effects of Pulsed Fields

#0799


Study into Biological Effects of Pulsed Electric and Magnetic Fields Produced upon Cellular Organism Renewal Systems for Developing New Prophylaxis and Therapy Methods

Tech Area / Field

  • BIO-RAD/Radiobiology/Biotechnology
  • MED-RAD/Radiomedicine/Medicine

Status
8 Project completed

Registration date
12.11.1996

Completion date
05.07.1999

Senior Project Manager
Kondratenkov Yu B

Leading Institute
Medical Radiological Scientific Center, Russia, Kaluga reg., Obninsk

Supporting institutes

  • VNIIEF, Russia, N. Novgorod reg., Sarov

Collaborators

  • Oregon Health Sciences University, USA, OR, Portland\nUniversity of Texas / Health Science Center at San Antonio, USA, TX, San Antonio

Project summary

The objective of the project is to study the mechanisms of biological effects produced by pulsed electric or magnetic fields upon cellular renewal systems of organisms (stern and committed cells in hematopoietic and immune systems, intestine epithelium, spermatogenic epithelium). Particular emphasis will be placed on the study of mechanisms responsible for the recently MRSC RAMS discovered effect of stimulating hematopoietic, immune and endocrine systems during the organism exposure to electric field of a specific resonance frequency range as well as to lowintensive electromagnetic field (EMF) (up to 10 mT) causing similar mainly immunostimulating effects, as has been found out by RFNC-VNIIEF specialists together with physicians of Nizhni Novgorod Medical Academy. The technical approach at the experimental stage includes the methods of present day radiobiology, oncology, hernatology, immunology and biophysics used to study the mechanism of EMF effects produced upon laboratory animals (mice, rats) and cell cultures in vivo and in vitro. During these investigations the mechanisms responsible for biological effects of pulsed electric and magnetic fields, relationships between the effects and physical field parameters will be studied and courses of treatment for different diseases including stress, inflammation, effects of radiation and chemical mutagens, tumor growth will be simulated. Particular attention will be given to scientific grounding of pulsed EMFs used in medical practice for diagnosis and therapy of different diseases. The obtained data will serve as a scientific basis for developing the medical apparatus, which will make it possible to correct the organism resistance to different harmful effects (ionizing radiation, chemical contaminants and stress-agents) and use as an adjuvant for treatment of cancer diseases, improving health of those harmful conditions or living on contaminated territories, and those whose work involves working under a great stress (operators of complex systems, pilots, seamen, etc.).

The activities are to result in a new scientific information on mechanisms responsible for biological effects produced by pulsed electromagnetic fields, as well as in development of new physiotherapeutic methods and medical apparatus, whose production can be arranged at conversion facilities.

Potential role of foreign collaborators

Professor Milton B.Yatvin is a distinguished expert in membrane biology. His attention of scientific project consultant is of crucial importance in an analysis of the mechanisms of initial reactions of biological effects of EMF on cellular membrane. It is suggested that professor M.B.Yatvin will arrive to Russia (Obninsk and Sarov) each year on 1 or 2 weeks for discussion and planning of new experiments.


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