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Crabs' Collagenase for Burn Treatment

#1034


Production of Collagenase from Crab Hepatopancreas for the Treatment of Burns

Tech Area / Field

  • MED-DRG/Drug Discovery/Medicine

Status
8 Project completed

Registration date
08.07.1997

Completion date
02.07.2001

Senior Project Manager
Pobedimskaya D D

Leading Institute
Russian Cardiology Research Center / Institute of Experimental Cardiology, Russia, Moscow

Supporting institutes

  • Research Center of Toxicology and Hygienic Regulation of Biopreparations, Russia, Moscow reg., Serpukhov

Collaborators

  • Novus Molecular, Inc., USA, CA, San Diego

Project summary

Methodology and approaches:
1. Isolation of collagenase from Kamchatka crab hepalopancreas.
2. Study on physicochemical and enzymological features of the collagen;
3. Elaboration of medicinal remedy of collagenase preparation.
4. Preclinical testing of a preparation.

Expected results:


1. As a result of realization of the project novelty obtained scientific data about features and ways of effective applications of collagenase preparations from Kamchatka crab hepatopancreas will be a subject of theoretical interest.
2. The developed new effective medicinal remedy for burn injuries, macerated and purulent wounds occurring on different tissues of human organism to decrease the time of reepithelization will be the subject of practical interest.

Possible themes of collaboration:


1. Physicochemical and enzymological features of enzyme preparations.
2. Study on immunotoxity and allergy of medicinal preparations.
3. Study of collagenase preparation action on process of blood trombosis.


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