Development and Research of New Biomaterials on the Basis of Polymers and Metal-Polymer Nanocompositions
Tech Area / Field
- BIO-CGM/Cytology, Genetics and Molecular Biology/Biotechnology
- CHE-POL/Polymer Chemistry/Chemistry
8 Project completed
Senior Project Manager
Crocker W E
National Academy of Sciences of Kyrgyzstan / Institute of Chemistry and Chemical Technology, Kyrgyzstan, Bishkek
- Cranfield University / School of Applied Sciences, UK, Bedford
Project summaryThis project is in the field of design of nanobiomaterials that to be used as substances for biological and pharmaceutical preparations. It is focused on creation of novel high-effective biologically active formulations of macromolecular nature to be applied as biomedical systems, namely magnetocontrolled drug delivery systems, nanoimmunosorbents for magnetic separation of cells, hybrid nanoassemblies with disinfectant (bactericidal, viricidal, fungicidal) and detoxification properties. As the result of the project implementation novel biomaterials on the base of polymer- and metal-polymer nanocomposites will be developed.
To reach these goals, the following research tasks will be set:
- To formulate various forms of surfactants on the base of natural polymers such as pectins, humic substances: water micelles, revertive micelles; monolayers, bilamellar liquid membranes.
- To obtain stabilized by indicated surfactants nanosystems on the base of some metals (Ag, Pt, Au, Fe, Cu, Co, Ni).
- To develop optimal methods for stabilization of multimetal nanoparticles using natural and synthetic polymers including interpolymer ones.
- To develop technology for production of nanometal-based magnet liquids.
- To design hybrid nanoassemblies with disinfectant and detoxification properties.
- To modify forms of anticancer and tumor chemosensitizing preparations on the base of pyrrolidone-carbonates, pectinates and pectates using nanometals.
- To perform the toxicological assessment of nanobiomaterials designed.
To reach this goal, the following technical approach will be undertaken:
The various surfactant systems will be received using pectins substances as stabilizators: water micelles, revertive micelles; monolayers, bilamellar liquid membranes.
To synthesize the various nanoparticles the state-of-the-art synthesis’ methods for nanomaterials will be used: sol-gel method, solid-phase sintering, mechanochemical synthesis, crystallization from solution into melt, gas-transport reactions, spray drying, hydrothermal processing, synthesis using microemulsions and liquid-crystal matrices, chemical reduction in liquid mediums). The method of spray pyrolysis is one of the most universal, high nonequilibrium methods of chemical homogenization to control micromorphology of particles. In this project the use of aerosols from solutions of nitrate complexes of iron (III) and sodium chloride with different ratio of functional and inert components will provide hollow oxide-salt microspheres in 0.1-2 microns size. Shell will consist of sub-micron crystals of NaCl including γ-Fe2O3 nanoparticles of 10-30 nm. Magnetic fluids resulting from such long-held non-toxic granules are stable in the form of colloidal solution within a few tens of hours and can be used as magneto-therapeutic drugs to hyperthermia.
The study of crystal structure and morphological features of nanostructured materials will be conducted using the methods of scanning and transmission electron microscopy, X-ray spectral microanalysis, X-ray analysis, the capillary absorption of nitrogen, scanning probe microscopy, infrared spectroscopy and Raman scattering spectroscopy.
For the binding and controlled release of various substances surface of polymer particles carriers will be functionalized. The release of such substances from mesoporous particles will be tested towards the model drugs - aspirin as hydrophilic and ibuprofen as hydrophobic materials.
Hybrid nanoassemblies of disinfectants will be received by conjugation of nanoparticles of native and modified pectin and humic substances with bactericidal, antivirus and fungicidal drugs. Detoxicants will be obtained by methods of chemical modification of pectin and humic substances.
The project will be performed by the group of Prof. Sh. Jorobekova from Institute of Chemistry and Chemical Technology of NAS KR and the group of Prof. A.D.Pomogailo. Their interests concern mainly the study of natural and synthetic polymers and nanocompositions. Publications relevant to the project are listed below:
- Jorobekova Sh. 1986: Macroligand properties of humic acids. Frunze, Ilim, 195 pp.
- Ashubaeva, S.D., Kozlova I.I. 1991: Metalcomplex derivatives of pectins and their use. Bishkek, Ilim, 94 pp. Aimukhamedova, G.B., Aliyev D.E., Shelukhina N.P. 1984: Properties and application of pectin sorbents. Frunze, Ilim, 116 pp.
- Jorobekova, Sh., Kydralieva, K.A, Alexandrov, V.G. 1998: The development of new humic acid-based products from the bioconversion of organic raw waste material and their application in agricultural and biopharmaceutical sectors. In: Proc. of ISTC Seminar. Bishkek, 98-101.
- Aimukhamedova G.B, et al. 1999: Potassium polygalacturonate with chemiosensitizing tumor effect. Kyrgyz prepatent, 318.
- Ushbaeva, G.G, et al. 2002: Availability of plant-based biopolymers for tumor corrective therapy. In: Materials Int. Conf. "Safety and life quality in big city". Almaty, 134-138.
- Aimukhamedova G.B, et al. 2003: Metalcomplexes of piroglutamin acid and polygalacturon as new anticancer compounds with a wide range of physiological and therapeutic effects. Journal of Kyrgyz National University, 3(1), 106-112.
- Aimukhamedova G.B., et al. 2004: Ni polygalacturonate with chemisensitizing tumor effect. Kyrgyz Patent, 712. Aymukhamedova, G.B., et al. 2004: Co polygalakturonate with chemisensitizing tumor effect. Kyrgyz Patent, 734.
- Pomogailo A.D., Rozenberg А.S., Uflyand I.E. 2000: Nanoparticles of metals in polymers, М.: Chemistry, 2000, 672 p.
- Pomogailo A.D., Kestelman V.N. 2005: Metallopolymer nanocomposites. Springer, Heidelberg, 563 p.
- Pomogailo A.D. 2006: Metallopolymer Nanocomposites. Macromolecular metallocomplexes as precursors for polymer, polymer-inorganic and bionanocomposites. Chapter in book “Metal and Metalloid Containing Macromolecules”, ed. by Ch. Carraher, Jr., C. Pittman, Jr., Abd-El-Aziz, M. Zeldin, and J. Sheats, Wiley-Interscience, John Wiley and Sons, Inc., New York, 2006, 7. Chapter 4. 87-220.
- Pomogailo A.D., Rozenberg A.S., Dzhardimalieva G.I. 2006: Controlled pyrolysis of metal-containing precursors as a way for syntheses of metallopolymer nanocomposites. Chapter in Book: “Metal-Polymer nanocomposites” (Eds. L. Nicolais, G. Carotenuto), Wiley, 2006, 75-122.
- Pomogailo A.D., Kestelman V.N. 2005: Nanobiocomposites. Chapter 9 in book “Metallopolymer nanocomposites”, Springer, 2005, 337-422
Fields of application and perspectives of commercialization
New systems containing nanometals and polymeric materials for application in medicine as substances for anticancer and chemosensitizing tumor drugs and drug delivery systems will be developed. Results and approaches of the project could be of interest for the leading producers of commercial fungicides, anticancer drugs (Novartis, Jansson-Silag).
International collaboration: Investigation of activity of nanobiopolymer systems will be accomplished in the Department of Nanotechnology of Cranfield University. It is headed by Prof. Ramsden well known specialist in creation of nanomaterials.