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Synthesis of Bio-active Metal-Complexes

#G-894


New Production Technologies of Raw Materials and Syntheses of Biologically Active Metal-Complexes on Their Base

Tech Area / Field

  • MAT-ALL/High Performance Metals and Alloys/Materials
  • CHE-SYN/Basic and Synthetic Chemistry/Chemistry
  • MED-DRG/Drug Discovery/Medicine
  • AGR-FOD/Food & Nutrition/Agriculture

Status
3 Approved without Funding

Registration date
31.05.2002

Leading Institute
Georgian Technical University, Georgia, Tbilisi

Collaborators

  • Rice University / Department of Chemistry, USA, TX, Houston\nKyushu University / Department of Chemistry, Japan, Fukuoka\nUniversity of Wyoming / Department of Chemistry, USA, WY, Laramie\nIllinois Institute of Technology / Armour College of Engineering & Science, USA, IL, Chicago

Project summary

The project proposes to exploit an energy saving, environmentally safe “green” technology-affording production of pure metals to provide metals used in medicine as essential nutrients. It is proposed to explore methods to converting metals in coordination compounds, utilizing the pure metals from our demonstrated low oxygen pressure process as bioviable precursors. Applications include medicines for both humans and animals, nutrients for humans, animals and plants, and also for microorganisms used in toxic waste management. This technology and the associated staff will thus be redirected towards peaceful long-term applications of our green technology. Microelements being present in albumens, ferments and hormones play an active role in all biological processes in the organism. Therefore, regulation of infringed metabolism, following different diseases, is of huge significance. Purposeful syntheses of coordination compounds with bioactive ligands based upon the “metals of life” and establishment of general regularities of triad “synthesis-structure-property” can successfully solve the most complicated problems of living matter. The purpose of the project is focused on development of the new economical, environmentally friendly production processes for pure bio-metals (Cu, Mn, Fe, Co, Ni) and some of the lowest oxides for direct synthesis of their coordination compounds with bioligands. Pure metals and some their lowest oxides will be obtained by thermal dissociation of corresponding higher oxides in a gaseous environment with ultra-low partial pressure of oxygen. The necessary gas atmosphere may be created in a closed system by removal of oxygen from its working volume, that according to our method allows to achieve within seconds superdeep cleansing of high-temperature reactor atmosphere from oxygen down to 10-26 atm. Thermal dissociation of practically any oxide is possible under these conditions.

Conversion of weapon-based-industrial complexes affords a problem of utilization of ferrous, non-ferrous and rare metals as well as of their oxides and salts. Most of them can be used after recycling as raw materials for synthesis of biologically active metal complexes. It is intended to conduct a direct syntheses of coordination compounds in solution by interaction of the reduced metals, and in some cases of their lowest oxides, with non-aqueous solutions of hydrazides of different carboxylic acids. Guanidine, aminoguanidine and histidine will be used as bioligands as well. Halide, sulphate, nitrate and thiocyanate will be applied as acid-derived ligands. The same ligands will be used to carry out ordinary syntheses in order to establish correlation among composition, molecular structure and biological activity of metal-complexes as well as for comparison with outcomes resulting from the new method of direct syntheses. We plan to perform the quantum-chemical calculations to predict donor abilities of the ligands in these complexes. This prediction will economize expenditure on reagents, duration of syntheses, and what is of great significance, it will give the predicted character to the synthesis. The produced metal-complexes will be tested in vitro and in vivo, and the most promising ones will be delivered for clinical tests in order to create new medical product.


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