Mechanisms of Photodynamic Therapy
Investigation of the Mechanisms of Photodynamic Therapy by Time-Resolved Radiospectroscopy
Tech Area / Field
- CHE-RAD/Photo and Radiation Chemistry/Chemistry
3 Approved without Funding
Russian Academy of Sciences / Kazan Physical-Technical Institute, Russia, Tatarstan, Kazan
- Federal Centre of Toxicological and Radiation Safety of Animals, Russia, Tatarstan, Kazan
- Dartmouth Medical School, USA, NH, Hanover
Project summaryThis project is aimed at studying the mechanisms of the primary photochemical reactions at photodynamic therapy (PDT) with the usage of time-resolved magnetic radiospectroscopy, the influence of the local dynamic temperature on the passing of these reactions and the developments of means to increase the spatial selectitivity of PDT.
For many years PDT is successfully used all over the world to treat oncological diseases. However, the exact mechanism of the processes taking place at PDT, in particular at the primary stage of the photochemical processes, is not completely clarified. The knowledge about these mechanisms will enable one to study the sequence and passing of reactions and to give recommendations on the purposeful search for the most effective regimes and conditions of PDT and on the creation of new photo-sensitizers.
The scientists engaged in the proposed project fall into two groups of researchers.
The first group comprises the scientists of the Kazan Physical-Technical Institute of the Kazan Scientific Center of the Russian Academy of Sciences (KPTI KSC RAS). KPTI is the leading institute of the Russian Academy of Sciences in the field of magnetic radiospectroscopy, the international scientific journal «Applied Magnetic Resonance» publishing the articles on the recent investigations in the field of magnetic radiospectroscopy is edited there. Recently the studies in the field of time-resolved magnetic radiospectroscopy on the unique EPR and NMR spectrometers are intensively carried out in the institute. The world-known specialists in the field of magnetic radiospectroscopy, in particular time-resolved spectroscopy, and radiobiology and chemical physics (a corresponding member of RAS, Dr.Sci.’s and Ph.D.’s) will participate in this project.
The second group of researchers comprises scientists and specialists from the All-Russian Research Veterinarian Institute (ARRVI). ARRVI is a large scientific center of the Veterinary Department of Rossel’khoz of the Ministry of Agriculture of the Russian Federation and the leading institute on the problems of veterinary radiobiology and toxicology. A large group of scientists-biologists having much experience in working with biological objects, in particular with cell culture, will participate in the project. At the first stage these objects will be used as model material. At the final stage to test the effectiveness of the obtained photo-sensitizers the experiments will be carried out on laboratory animals. These investigations will carried out by highly qualified specialists in the field of radiobiology and toxicology (Dr. Sci.’s and Ph.D.’s).
The proposed project is in full conformity with the goals and objectives of ISTC.
- The project will enable the highly qualified scientists and specialists, previously busy with the development of technologies for the defense from the nuclear-missile and biological weapon, to re-direct their capabilities to the peaceful activities.
- The project will enable the support of the applied and fundamental investigations in the filed of biotechnologies and life science.
- The project encourages the involvement of specialists previously occupied with the production of weapons of mass destruction and defense technology into the international collaboration.
It is supposed that the well-known American scientist in the field of biomedicine and application of magnetic resonance in biology and medicine, Director of the EPR Center for the Study of Viable Systems at Dartmouth Medical School Professor H. Swartz, will be the Project Collaborator. The role of the foreign collaborator includes the following:
- Exchange of information and discussion of the obtained results.
- Assistance in working out proposals within the project.
- Conduction of joint workshops and meetings.
- Joint usage of the unique equipment.
The proposed duration of the project is 3 years, the effort is 391 people*month.