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Diagnosing of Poisoning Cases with Organic Phosphate Substances

#2345


Developing a Computer Software Program: Differential Diagnosing of Acute Poisoning Cases with Organic Phosphate Substances

Tech Area / Field

  • INF-SOF/Software/Information and Communications
  • CHE-OTH/Other/Chemistry

Status
8 Project completed

Registration date
15.10.2001

Completion date
18.10.2004

Senior Project Manager
Rybakova T A

Leading Institute
Scientific Research Institute of Hygiene, Toxicology and Occupational Pathology, Russia, Volgograd reg., Volgograd

Supporting institutes

  • South Center for Medical and Sanitary Assistance under Chemical Emergency, Russia, Volgograd reg., Volgograd\nSt Petersburg State Polytechnical University / Scientific Engineering Center, Russia, St Petersburg

Collaborators

  • Atlantic Logistics, Inc., USA, NJ, Collingswood\nLawrence Livermore National Laboratory / Health & Ecological Assessmant (HEA) Division, USA, CA, Livermore

Project summary

The purpose of this Project is to develop a new software product for detection of various groups of organic phosphorous compounds that cause acute poisoning exposure.

Organic phosphates belong to a group of chemicals that most frequently cause acute exposure to hazardous commercial chemicals. Besides this chemical class includes a group of weapon grade agents. Recent incidents demonstrate that terrorists can use that group of chemical agent for purposes of mass exposure of populations. The exposure mechanisms of commercial and weapon grade organic phosphorous chemicals are basically similar; this is why clinical features of poisoning with both groups have very much in common. Chemical analysis methods that are commonly used are also mainly focused on detection of the chemical class of substances that cause the poisoning effect as organic phosphorous compounds. In other words they are not sufficiently specific.

Mass (or group) exposures pose special complexity when the disease does not manifest clear etiology. Researchers of the South Center for Medical and Sanitary Assistance under Chemical Accidents SCCE) have developed a new recognition methodology to recognize chemicals in cases of unclear etiology (DEFIT). The researchers of SCCE in collaboration with the Research Institute of Hygiene, Toxicology and Occupational Pathology developed the DePhos software program as an upgraded version. DePhos program allows the user to detect whether the exposure was caused by weapon grade substances (sarin, soman) or by organic phosphorous pesticides. However the group of organic phosphorous pesticides includes a large number of substances that differ by chemical structure. Besides the DePhos program does not determine the gravity of the exposure. Those shortcomings of the DePhos software program prompt the main purpose of this Project.

Main objectives of the development are the following:

  • Database formation;
  • Adaptation of DePhos program to the DELPHY instrument system;
  • Validation of the recognition efficiency of the algorithm for organic phosphorous substances, which was developed earlier by Boris N. Filatov and Elena V. Boulanova;
  • Detection mechanism for the emergence and persistence of acute exposure caused by different chemical classes, which rests on a new system analysis paradigm technology (СOMOD);
  • Completion of the new interface for the software program in English and in Russian.

As a result of the Project completion there will be a software product, which will enable medical doctors to resolve in a timely manner detection tasks for acute exposure to organic phosphorous chemicals. That will improve the efficiency of expert investigation for cases with unclear etiology when there is reason to suspect poisoning with organic phosphorous substances; and such detection will accordingly improve medical treatment.

The Project duration is 18 months. In this Project toxicologists will be involved who have extensive experience in handling poisonous substances, software engineers who are authors of various software products, and mathematicians who specialize in system analysis methods. Lawrence Livermore National Laboratory(LLNL) has agreed to participate in the Project as a collaborator; Dr. Jeffrey Daniels, a leading LLNL officer has taken active part in the development of the DEFIT software program as DOE Technical Representative.


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