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Nano-Structured Kadmium Preparation for Treatment of Cancer

#4062


Construction of New Therapeutic Agents Based on Nanoparticles, Consisting of Cadmium and Food Plant Pigments for Neutron Capture-, Photodynamic- and Chemotherapy of Oncological Diseases

Tech Area / Field

  • MED-DRG/Drug Discovery/Medicine
  • MED-RAD/Radiomedicine/Medicine

Status
3 Approved without Funding

Registration date
16.04.2010

Leading Institute
Cancer Research Center, Russia, Moscow

Supporting institutes

  • Russian Academy of Sciences / A. N. Bach Institute of Biochemistry, Russia, Moscow\nInstitute of Immunological Engineering, Russia, Moscow reg., Lyubuchany

Collaborators

  • Clinical Trials, Germany, Emmendingen

Project summary

The goal of the project is to create new therapeutic agents based on nanoparticles, consisting of cadmium and phycoerythrin for the therapy of oncological diseases.

Much attention is paid to creation of the methods of neutron capture- and photodynamic therapy at the treatment of cancer and other diseases. Cadmium is known for its positive effect in respect of oncological diseases. The disadvantage of cadmium use is its high general toxicity. Science novelty of the Project is creating and using nanoparticles containing cadmium in complex with R-phycoerythrin, protein being used in food industry as a vegetable dye.

R-phycoerythrin, a photosynthetic pigment of red algae, represents a complicated high molecular weight protein having identical cavities as the nanocanals (3.5 x 6nm) in the center of molecules, which are essentially for uniform-sized nanoparticles synthesis. The content of phycoerythrin in algae achieves 60% of the total protein, it’s easily extracted. Phycoerythrin is water-soluble, high fluorescent, its chromophor groups are similar to the human bile pigment. Phycobilin pigments are able to generate active oxygen species. In photodynamic therapy phycobiliproteins are more effective in comparison with widely used hematoporphyrin derivates. The Project participants have obtained cadmium/phycoerythrin complex perspective for neutron capture and chemotherapy use for the first time. The investigations of CdS nanoparticle photochemical properties on phycoerythrin matrix in model systems have demonstrated their advantage for photodynamic therapy use.

Cd-phycoerythrin complex is stable enough and convenient for modification in order to increase the selectivity to malignant cells. This will enable the inpidual approach to the treatment selecting the most adequate therapy protocol for each patient.

The Project provides:

  • the preparation of Cd-phycoerythrin and Cd113 -phycoerythrin nanosized complexes in water solution;
  • the obtaining of modified Cd-phycoerythrin nanosized complexes selective to different cancer cells;
  • a study of photosensitizing capability of CdS-phycoerythrin nanoparticles in tumor cell line panel and in laboratory animals with grafted tumors;
  • a study of a possibility of selective to malignant cells nanosized Cd113-phycoerythrin complex use for neutron capture therapy in cellular models.

The Project participants have all the necessary conditions for successive project completion.


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