Arbovirus infections in Kyrgyz Republic
The estimation of Potential Biological Danger from Natural Arbovirus Foci in Kyrgyz Republic with a Help of Modern Molecular-Genetic Methods, Studying of Isolated Viruses and Development of Diagnostic Preparations
Tech Area / Field
- ENV-EHS/Environmental Health and Safety/Environment
- MED-DIS/Disease Surveillance/Medicine
- ENV-MIN/Monitoring and Instrumentation/Environment
8 Project completed
Senior Project Manager
Weaver L M
Republican Center of Quarantine and Especially Dangerous Infections, Kyrgyzstan, Bishkek
- State Sanitary Epidemiological Supervision Department, Kyrgyzstan, Bishkek\nNational Academy of Sciences of Kyrgyzstan / Biotechnology Institution, Kyrgyzstan, Bishkek
- Florida Gulf Coast University, USA, FL, Fort Meyers\nNaval Medical Research Center / US Naval Medical Unit 3 / US Naval Medical Center/US Naval Medical Unit 3, Cairo, Egypt, Egypt, Cairo\nNaval Medical Research Center / US Naval Medical Unit 3, USA, MD, Silver Spring\nForeign Affairs Canada, Canada, ON, Ottawa
Arboviral infections being feral nidal infections are the main source of the human diseases in nature. Besides nowadays the probability of the deliberate infection spreading with the help of bio agents, including arboviruses is one of the most serious problems.
Essential moment in providing biological safety for public health is effective system of pathogens identification and estimation of epidemiological situation.
Etiological identification of the arboviruses usually is embarrassed by the great variety of pathogenic organisms and can be provided only by the well-arranged laboratory diagnostics.
Such factors as arboviral wide spreading, diagnostic difficulties, lack of funds for preventive measures and possibilities of epidemiological situation deterioration in order to economic and migration activities of population necessitate the permanent epidemiological supervision of natural arbovirus’ foci.
The actuality of the problem confirms by the following factors as increasing of arboviral infection activity, appearing of new natural foci and restoring of the old ones.
There are 12 natural arboviruses’ foci on the territory of Kyrgyz Republic: tick-borne encephalitis, Crimean Congo hemorrhagic fever, arboviruses of Issik-Kul, Sindbis, Tamdy, Bhandja, Baku, Batken, Tulek, Sokuluk, Burana and Naukat. The last 5 of them were revealed in Kyrgyz Republic and they are not studied enough.
The natural conditions and birds’ flyways make it possible to forecast appearing of not revealed yet natural pestholes and carrying such pestholes from contiguous territories.
Spreading of the arbovirus infections on the territory of the Republic is not equal. Zones with the most favorable conditions for arboviruses circulation are the southern part (Fergana region) of the Republic. There was revealed circulation of 10 species of arboviruses.
Arbovirus’ natural foci state had been studying for many years in Kyrgyz Republic in close cooperation with bases of All-Union Ecology Centers of pathogenic organisms, which were the part of antiterrorist system of USSR. Nowadays the partnership is broken. Limited budget doesn’t allow keep the natural foci under control.
The results of the last researches show the great biological potential of arboviruses’ foci in Republic. Epidemiological danger of the natural arbovireses’ foci is determined by the following factors as pestholes’ location in plains and foothills, where the most settlements are centered and where is the highest density of population.
Not enough attention was paid to the role of arboviruses in human pathology. Most likely those diseases with arboviral etiology belong to other nosological groups.
Project implementation will allow resuming systematical research of the natural arbovirus’ foci, estimating present state of the existing pestholes and revealing the new ones on the territory of our Republic.
Such tasks as immunochemical description of isolates, identification of nucleotide genome sequence in field samples and in collections of viral cultures, besides comparison of the results of nucleotide genome sequence in arboviruses are included in project.
One of the main problems, which are in the frame of the project, is development of standard diagnostic agents under laboratory conditions in order to the lack of commercial production of such agents.
The development of the diagnostic agents on the basis of isolated arboviruses with the help of up-to-dated methods will give possibility to carry out monitoring of the foci and diagnostics of arboviral human diseases more qualitatively.