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Effects of Ammonia and Heavy Metals on Heart, Brain and Intestine

#2531


Studies on the Effects of Ammonia, Heavy and Rare Metals on Animal Heart, Brain and Intestine in Order to Create Diagnostic Methods for Cardio-Vascular, Neurological and Gastro-Intestinal Diseases

Tech Area / Field

  • MED-DID/Diagnostics & Devices/Medicine
  • BIO-CHM/Biochemistry/Biotechnology
  • MED-DRG/Drug Discovery/Medicine

Status
3 Approved without Funding

Registration date
11.06.2002

Leading Institute
Institute of Cell Biophysics, Russia, Moscow reg., Puschino

Supporting institutes

  • VNIIEF, Russia, N. Novgorod reg., Sarov\nNational Hematology Research Center, Russia, Moscow\nInstitute of Theoretical and Experimental Biophysics, Russia, Moscow reg., Puschino

Collaborators

  • University of Nebraska / Institute of Agriculture and Natural Resources, USA, NE, Lincoln\nColumbia University / College of Physicians & Surgeons / Department of Neurology, USA, New York\nInstituto de Investigaciones Citolsgicas/ Fundacion Valensiana de Investigaciones Biomidicas, Spain, Valencia

Project summary

The main objective of the project is to study the effects of ammonia, heavy and rare metals on animal heart, brain and intestine in order to create diagnostic methods for cardio-vascular, neurological and gastro-intestinal diseases.

The specific objectives of the project can be summarized as follows:

1) To develop the technology for production of water-soluble salts of ammonia, heavy and rare metals applicable for the administration into animals, and to produce these salts in necessary amounts.


2) To develop the technology for investigating heart muscle, brain, and epithelial intestinal cells from animals exposed to ammonia and metals, by electron microscopy methods that allow to access quantitatively metal permeation into the cell.
3) To study the morphologic and biochemical effects of ammonia, heavy and rare metals on animal heart muscle, brain and epithelial intestinal cells in vivo and in vitro.
4) To elucidate the possibility of usage of some compounds as protectors from toxic damage to the heart muscle, brain and epithelial intestinal cells after animals were exposed to ammonia, heavy and rare metals.
5) To formulate general recommendations for diagnostics and prophylaxis of cardio-vascular, neurological and gastro-intestinal diseases associated with toxic effects of ammonia, heavy and rare metals.


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