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Monograph "Mathematical Modeling of Radiation Effects on Mammals"

#2181


Monograph "Mathematical Modeling of Radiation Effects on Mammals"

Tech Area / Field

  • ENV-MRA/Modelling and Risk Assessment/Environment

Status
8 Project completed

Registration date
24.04.2001

Completion date
14.09.2004

Senior Project Manager
Kulikov G G

Leading Institute
Research Testing Center for Radiation Safety of Space Objects, Russia, Moscow

Supporting institutes

  • NIIIT (Pulse Techniques), Russia, Moscow

Collaborators

  • University of Tennessee / College of Arts and Sciences, USA, TN, Knoxville\nLyndon B. Johnson Space Center, National Aeronautics and Space Administration, USA, TX, Houston\nJustus-Liebig-Universität Giessen, Germany, Giessen

Project summary

The Project is a fundamental theoretical research in the field of environmental protection. Its implementation will result in writing and preparing for publication a monograph which summarizes results of investigations of radiation effects on mammals by making use of mathematical modeling methods. The most part of the material, that will be included into the book, is the results obtained by the author herself during last 25 years, bulk of them being of priority ones. Specifically, it concerns the modeling, in the framework of a unique approach, of effects of acute and chronic irradiation on major critical systems of mammalian organism (hematopoiesis and small intestine), the simulating of radiation effects on the humoral immunity and on the development of autoimmune diseases, as well as the modeling of the dynamics of radiation-induced mortality in mammalian populations which are homogeneous and nonhomogeneous in radiosensitivity. These investigations are important for fundamental science because they develop system and quantitative approaches in radiation biology and ecology, give quantitative estimations of key parameters characterizing the processes running in exposed organism. The modeling of paradoxical effects of low level irradiation, that still do not have unambiguous interpretations, is of special theoretical significance. The material, that will be presented in the monograph, is a matter of interest to practical use, too. So, the elaborated models lay down theoretical foundations of a new approach to the radiation risk assessment which is based on the allowance for the state of the respective critical system in irradiated organism and its inpidual radiosensitivity. This approach can be applied at high and, that is most important, at low levels of radiation. Besides, in the course of modeling investigations a criterion is found which enables one, using routine blood sampling, to reveal groups of radiation risk (hyperradiosensitive inpiduals) among people exposed to small dose rate chronic radiation. Obviously, employment of this criterion in medical practice allows one to carry out more effectively preventive and protective measures among population residing in nuclear contaminated areas and also among persons subjected to occupational irradiation. Thus, the implementation of the Project will result in preparing the monograph that is necessary for specialists working in the field of mathematical modeling of biological systems, as well as in the field of radiation biology, ecology, and medicine. The book can be used as a basis for a lecture course on mathematical modeling in radiobiology and radioecology for students and postgraduate students of appropriate specializations. It should be stressed that the Project meets goals and objectives of the ISTC. Namely, the implementation of the Project will promote the redirection of weapon scientists to solving the urgent problems of radiation biology and ecology, where their expertise and experience can be used effectively. In the framework of the Project weapon scientists will be integrated into the international scientific community due to the interchange of information with abroad collaborators. In addition, the realization of the Project will support basic research for peaceful purposes, namely, in the field of environmental protection.


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