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Cardiovascular Drugs

#0870


Isolation of Active Substances from Natural Sources and their Synthesis for the Development of Highly Effective Cardiovascular Drugs

Tech Area / Field

  • BIO-CHM/Biochemistry/Biotechnology
  • MED-DRG/Drug Discovery/Medicine

Status
8 Project completed

Registration date
21.02.1997

Completion date
08.07.2003

Senior Project Manager
Evstyukhin K N

Leading Institute
State Research Institute of Organic Chemistry and Technology, Russia, Moscow

Supporting institutes

  • Russian Cordiology Research Center, Russia, Moscow

Collaborators

  • US Department of Health & Human Services / National Institute of Health / National Heart, Lung and Blood Institute, USA, MD, Bethesda

Project summary

Atherosclerosis-related cardiovascular diseases are the main cause of a rising mortality in Russia and developed countries. However, the development of effective antiatherosclerotic drugs with a direct effect on atherosclerotic plaques is still an unsolved but very perspective task.

In the development of new antiatherosclerotic substances, naturally occurring components, which are widely used in folk medicine for prevention and treatment of cardiovascular diseases, are of special interest. Thus, garlic and garlic preparations were early shown to be capable of reducing the risk of cardiovascular diseases caused by development of atherosclerosis. As it was proved by specialists from Russian Cardiology Research Center in experiments with atherosclerotic human aorta cells used as model, water extracts from dried garlic had antiatherosclerotic effect. It is necessary to note that the most physiologically active garlic components are unstable substances, and, therefore, they are of limited value as potential pharmacological agents. Indeed, studies in the field of synthesis of highly efficient and stable analogs of naturally occurring substances (e.g. garlic components) are very perspective.

The aim of this Project is to design potential substances with a direct antiatherosclerotic effect on the basis of pharmacologically active components of natural products, e.g. garlic. To solve the Project tasks, bioactive substances having the antiatherosclerotic effect on chosen pharmacological models will be isolated from natural material, their chemical structures will be determined, and the most promising substances and their analogs will be synthesized.

Besides the commonly accepted procedures, the supercritical fluid extraction and chromatography methods that are successfully developed in SRIOCT will be used for isolation of the substances. The antiatherosclerotic activity will be studied in RCRC with the use of a unique model of atherosclerotic aorta cells.

At the structure determination and synthesis of active components, the great experience of SRIOCT specialists in the field of physiologically active substances (including naturally occurred ones) will be used.

The objectives and activities of this Project completely comply with scientific research programs in SRIOCT and RCRC.

During execution of this Project the scientists and other specialists whose previous area of expertise was related to the development of highly toxic agents will have an opportunity to redirect their activity to solving such peaceful tasks as design of new drugs.

The Project authors welcome the involvement of Western or Japanese scientists, whose scientific interests lie in the Project field. Foreign collaborators will get the opportunity of scientific information exchange, steady scientific contact with the Project Manager and visiting the Project during the work. The collaborator therefore benefits from receiving the latest information concerning the project work results.


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